Document Detail

Association of plaque echostructure and cardiovascular risk factors with symptomatic carotid artery disease.
MedLine Citation:
PMID:  19998256     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Severity of stenosis remains the main factor for assessing risk of stroke in patients with internal carotid artery (ICA) disease. This study was conducted to investigate the association of plaque echostructure and other established and emerging cardiovascular risk factors with symptomatic ICA disease.
DESIGN: Cross-sectional study of consecutive patients with significant (> 50%) ICA stenosis.
PATIENTS AND METHODS: Carotid plaque echostructure, smoking, hypertension, diabetes mellitus, serum lipoprotein (a), homocysteine, vitamin B12, folate, cholesterol to high-density lipoprotein ratio, triglycerides, C-reactive protein, and the Framingham risk score were assessed in 124 consecutive patients (70 asymptomatic; 54 symptomatic) with significant (> 50%) ICA stenosis.
RESULTS: The asymptomatic and symptomatic groups did not differ in terms of gender distribution (p = 0.76) and severity of stenosis (p = 0.62). Echolucent plaques (type 1 and 2) were more predominant in patients with symptomatic disease (p = 0.004, OR = 2.13, 95% CI = 1.26-3.6). Patients with plaques type 1 were relatively younger than those with type 4 (p = 0.02). None of the other factors assessed had any significant association with symptomatic disease and any type of carotid plaque.
CONCLUSIONS: Besides the severity of carotid stenosis, the presence of an echolucent plaque appears as an important factor associated with symptomatic ICA disease. Also, young patients are more likely to have an echolucent plaque suggesting an age-related association with plaque maturation.
A D Giannoukas; G S Sfyroeras; M Griffin; V Saleptsis; G A Antoniou; A N Nicolaides
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  VASA. Zeitschrift für Gefässkrankheiten     Volume:  38     ISSN:  0301-1526     ISO Abbreviation:  VASA     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-12-09     Completed Date:  2010-02-04     Revised Date:  2012-10-19    
Medline Journal Info:
Nlm Unique ID:  0317051     Medline TA:  Vasa     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  357-64     Citation Subset:  IM    
Imperial College School of Medicine, London, U.K.
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MeSH Terms
Age Factors
Cardiovascular Diseases / etiology*,  ultrasonography
Carotid Artery, Internal / ultrasonography*
Carotid Stenosis / complications,  ultrasonography*
Cross-Sectional Studies
Odds Ratio
Risk Assessment
Risk Factors
Severity of Illness Index
Time Factors
Ultrasonography, Doppler, Duplex*

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