| Association of physical training with beta-blockers in heart failure in mice. | |
| | |
MedLine Citation:
|
PMID: 20676588 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
BACKGROUND: Currently there are several types of interventions for the treatment of heart failure (HF). Among these are beta-blocker therapy (BB) and physical training (PT). However, the effects of the combination of these therapies are poorly studied. OBJECTIVE: To investigate the effects of BB treatment with metoprolol (M) and carvedilol (C) associated with PT in mice with HF. METHODS: We used a genetic model of sympathetic hyperactivity-induced heart failure in mice. Initially, we divided the HF animals into three groups: sedentary (S); trained (T); treated with M (138 mg/kg) (M); or C (65 mg/kg) (C). In the second part, we divided the groups into three subgroups: sedentary (S); trained and treated with M (TM); and trained and treated with C (CT). The PT consisted of aerobic training on a treadmill for 8 weeks. Exercise tolerance was assessed by maximal graded test, and fractional shortening (FS) was assessed by echocardiography. Cardiomyocyte diameter and collagen volume fraction were evaluated by histological analysis. Data were compared by one way ANOVA and post hoc Duncan test. The significance level was set at p ≤ 0.05. RESULTS: As to FS and cardiac remodeling, we found that, in isolation, T, M, and C showed an improvement of the variables analyzed. As to therapy combination, after the intervention period, we observed an increase in exercise tolerance in MT and CT (43.0% and 33.0% respectively). There was also a reduction in cardiomyocyte diameter (10.0% and 9.0% respectively) and in collagen volume fraction (52.0% and 63.0%) after the intervention. However, only CT significantly improved FS. CONCLUSION: The association of PT with M or C therapies provided benefits on cardiac function and remodeling in HF mice. |
| | |
Authors:
|
Andréa Somolanji Vanzelli; Alessandra Medeiros; Raquel de Assis Sirvente; Vera Maria Cury Salemi; Charles Mady; Patricia Chakur Brum |
Related Documents
:
|
6860298 - Characterization of superoxide dismutase (sod-1 and sod-2) activities in inbred mice: e... 18428038 - Targeted disruption of slc2a8 (glut8) reduces motility and mitochondrial potential of s... 8576868 - A study of the role of corticosterone as a mediator in exercise-induced stimulation of ... 11740298 - Interstrain variation in murine aerobic capacity. 3287548 - Exercise and the immune response. 2058788 - Male physical aggression as a function of alcohol intoxication and frustration: experim... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-30 |
Journal Detail:
|
Title: Arquivos brasileiros de cardiologia Volume: 95 ISSN: 1678-4170 ISO Abbreviation: Arq. Bras. Cardiol. Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-10-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0421031 Medline TA: Arq Bras Cardiol Country: Brazil |
Other Details:
|
Languages: eng Pagination: 373-80 Citation Subset: IM |
Affiliation:
|
Universidade de São Paulo, Brazil. vanzelli@usp.br |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Rosiglitazone and vascular injury in hypercholesterolemic rabbits: neointimal formation assessment.
Next Document: Brazilian academic search filter: application to the scientific literature on physical activity.