Document Detail

Association of physical activity with all-cause mortality and incident and prevalent cardiovascular disease among patients with type 1 diabetes: the EURODIAB Prospective Complications Study.
MedLine Citation:
PMID:  23052062     Owner:  NLM     Status:  MEDLINE    
AIMS/HYPOTHESIS: The aim of this study was to examine the association of physical activity (PA) with all-cause mortality and incident and prevalent cardiovascular disease (CVD) among patients with type 1 diabetes.
METHODS: The EURODIAB Prospective Complications Study is a cohort including 3,250 male and female patients with type 1 diabetes (mean age 32.7 ± 10.2 years) from 16 European countries, of whom 1,880 participated in follow-up examinations. In analysis 1 (longitudinal), the association of baseline PA (based on the reported number of hours per week spent in mild, moderate and vigorous PA) with all-cause mortality and incident CVD was examined by performing survival analysis. In analysis 2 (cross-sectional), we focused on the association between PA at follow-up (data on sports, walking distance and regular bicycling) and prevalent CVD by performing logistic regression analysis. Adjustments were made for age, sex, BMI, smoking, consumption of alcohol, consumption of certain nutrients and diabetic complications.
RESULTS: Analysis 1 (longitudinal): participation in moderate or vigorous PA once a week or more was borderline inversely associated with all-cause mortality (men and women combined) (HR 0.66, 95% CI 0.42, 1.03) and incident CVD (women only) (HR 0.66, 95% CI 0.40, 1.08). No association was found in men. Analysis 2 (cross-sectional): total PA (indexed by sports, walking, bicycling) and distance walked were inversely associated with prevalent CVD (OR(totalPA) 0.66, 95% CI 0.45, 0.97; and OR(walking) 0.61, 95% CI 0.42, 0.89).
CONCLUSIONS/INTERPRETATION: PA showed a borderline inverse association with both all-cause mortality (both sexes) and incident CVD (women only) in patients with type 1 diabetes. Since this is an under-researched clinical population, future longitudinal studies with objective PA measurements are needed to expand on these results.
S M A J Tielemans; S S Soedamah-Muthu; M De Neve; M Toeller; N Chaturvedi; J H Fuller; E Stamatakis
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-10
Journal Detail:
Title:  Diabetologia     Volume:  56     ISSN:  1432-0428     ISO Abbreviation:  Diabetologia     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-18     Completed Date:  2013-05-28     Revised Date:  2014-03-14    
Medline Journal Info:
Nlm Unique ID:  0006777     Medline TA:  Diabetologia     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  82-91     Citation Subset:  IM    
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MeSH Terms
Cardiovascular Diseases / epidemiology*,  mortality,  prevention & control
Cohort Studies
Cross-Sectional Studies
Diabetes Mellitus, Type 1 / complications,  epidemiology,  mortality*,  therapy
Diabetic Angiopathies / complications,  epidemiology*,  mortality,  prevention & control
Diabetic Cardiomyopathies / complications,  epidemiology*,  mortality,  prevention & control
Europe / epidemiology
Follow-Up Studies
Longitudinal Studies
Middle Aged
Motor Activity*
Prospective Studies
Sex Factors
Young Adult
Grant Support
CDF-2010-03-30//Department of Health; PDA/03/07/056//Department of Health; //Wellcome Trust

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