Document Detail

Association of phenylbutazone usage with horses bought for slaughter: a public health risk.
MedLine Citation:
PMID:  20176071     Owner:  NLM     Status:  MEDLINE    
Sixty-seven million pounds of horsemeat derived from American horses were sent abroad for human consumption last year. Horses are not raised as food animals in the United States, and mechanisms to ensure the removal of horses treated with banned substances from the food chain are inadequate at best. Phenylbutazone (PBZ) is the most commonly used non-steroidal anti-inflammatory drug (NSAID) in equine practice. Thoroughbred (TB) race horses like other horse breeds are slaughtered for human consumption. Phenylbutazone is banned for use in any animal intended for human consumption because it causes serious and lethal idiosyncratic adverse effects in humans. The number of horses that have received phenylbutazone prior to being sent to slaughter for human consumption is unknown but its presence in some is highly likely. We identified eighteen TB race horses that were given PBZ on race day and sent for intended slaughter by matching their registered name to their race track drug record over a five year period. Sixteen rescued TB race horses were given PBZ on race day. Thus, PBZ residues may be present in some horsemeat derived from American horses. The permissive allowance of such horsemeat used for human consumption poses a serious public health risk.
Nicholas Dodman; Nicolas Blondeau; Ann M Marini
Publication Detail:
Type:  Journal Article     Date:  2010-02-20
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  48     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-14     Completed Date:  2010-07-06     Revised Date:  2012-04-13    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1270-4     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Ltd.
Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, USA.
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MeSH Terms
Abattoirs* / legislation & jurisprudence
Anti-Inflammatory Agents, Non-Steroidal / adverse effects,  analysis*
Consumer Product Safety
Drug Residues / adverse effects,  analysis*
Food Contamination / analysis*,  legislation & jurisprudence
Meat / analysis*,  standards
Phenylbutazone / adverse effects,  analysis*
Risk Assessment
United States
United States Department of Agriculture / legislation & jurisprudence
United States Food and Drug Administration / legislation & jurisprudence
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 50-33-9/Phenylbutazone
Comment In:
Food Chem Toxicol. 2012 Mar;50(3-4):603; author reply 455-6   [PMID:  22245664 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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