Document Detail


Association of perforation of the appendix with female tubal infertility.
MedLine Citation:
PMID:  11257064     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although perforation of the appendix is considered a risk factor for female tubal infertility, the epidemiologic evidence supporting this relation is inconsistent. Risk factors for tubal infertility were compared for 121 women with documented primary tubal infertility attending in vitro fertilization clinics in Toronto, Canada, from July to December 1998 and 490 controls who were pregnant during the same time period. Self-administered questionnaires and review of medical records were used to assess exposures. The authors found that neither history of acute appendicitis nor perforation of the appendix was a statistically significant risk factor for tubal infertility. The crude odds ratio for perforated appendicitis was 3.4 (95% confidence interval (CI): 0.9, 12.9), and the adjusted odds ratio was 1.4 (95% CI: 0.3, 6.2). In addition to increased age and annual income, cigarette smoking (odds ratio (OR) = 2.0, 95% CI: 1.2, 3.2), history of endometriosis (OR = 6.0, 95% CI: 2.8,12.8), and history of pelvic inflammatory disease (OR = 6.0, 95% CI: 2.8, 12.8) were significantly associated with tubal infertility in multivariate analysis. These data do not provide substantial evidence that perforation of the appendix is an important risk factor for female tubal infertility.
Authors:
D R Urbach; L D Marrett; R Kung; M M Cohen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of epidemiology     Volume:  153     ISSN:  0002-9262     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-03-21     Completed Date:  2001-04-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  566-71     Citation Subset:  IM    
Affiliation:
Department of Surgery, University of Toronto, Toronto, Ontario, Canada. david.urbach@uhn.on.ca
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MeSH Terms
Descriptor/Qualifier:
Adult
Bias (Epidemiology)
Case-Control Studies
Chi-Square Distribution
Female
Humans
Infertility, Female / epidemiology,  etiology*
Intestinal Perforation / complications*,  epidemiology
Logistic Models
Ontario / epidemiology
Pregnancy
Prevalence
Questionnaires
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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