Document Detail

Association of parental history of stroke with clinical parameters in patients with ischemic stroke or transient ischemic attack.
MedLine Citation:
PMID:  12920259     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: Data regarding hereditary influences on stroke remain controversial. We investigated possible associations of a family history of stroke with clinical parameters in a large cohort of well-documented patients with ischemic cerebrovascular events, with special reference to sex-specific differences. METHODS: We analyzed the association between a maternal and/or paternal history of stroke and clinical parameters in 1564 patients with known maternal and paternal history of stroke and suffering from ischemic stroke or transient ischemic attack within the Vienna Stroke Registry. RESULTS: Patients with a maternal history of stroke were significantly more often female (54%) than those without (44%; P=0.003). Hypertension was more prevalent in female patients with than in those without a maternal history of stroke (87% versus 74%; P=0.001). These associations remained significant after multivariate adjustment (adjusted odds ratio, 1.9; 95% CI, 1.1 to 3.5; P=0.024). Of those female patients with an echocardiogram (n=225), those with a maternal history of stroke more often had left ventricular hypertrophy (48%) than those without (20%) (adjusted odds ratio, 3.6; 95% CI, 1.5 to 8.2; P=0.003). In contrast, hypertension was equally prevalent in male patients with or without a maternal history of stroke (75% versus 74%; P=0.754). We found no significant associations of clinical parameters with a paternal history of stroke. CONCLUSIONS: Our results indicate a sex-specific relationship between a maternal history of stroke and the prevalence of hypertension and left ventricular hypertrophy in female patients with ischemic cerebrovascular events.
S Tentschert; S Greisenegger; R Wimmer; W Lang; W Lalouschek
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2003-08-14
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  34     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-05     Completed Date:  2003-10-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2114-9     Citation Subset:  IM    
Clinical Department of Clinical Neurology, University Clinic of Neurology, University of Vienna, Austria.
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MeSH Terms
Austria / epidemiology
Brain Ischemia / epidemiology,  genetics*
Cohort Studies
Hypertension / epidemiology
Hypertrophy, Left Ventricular / epidemiology
Ischemic Attack, Transient / epidemiology,  genetics*
Logistic Models
Middle Aged
Multivariate Analysis
Odds Ratio
Prospective Studies
Registries / statistics & numerical data
Sex Distribution
Sex Factors
Stroke / epidemiology,  genetics*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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