Document Detail


Association of p63 with proliferative potential in normal and neoplastic human keratinocytes.
MedLine Citation:
PMID:  10594758     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
p63, a recently identified member of the p53 gene family, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. We show that in normal human epidermis, in hair follicles, and in stratified epidermal cultures, p63 protein is principally restricted to cells with high proliferative potential and is absent from the cells that are undergoing terminal differentiation. In normal human epidermis and in hair follicles, basal cells with abundant p63 are interspersed with cells with little or no p63. Whenever p63 mRNA is present, it encodes mainly truncated, potentially dominant-negative isotypes. In squamous cell carcinomas, the number of cells containing p63 and their distribution depends on the degree of anaplasia. In highly differentiated tumors, p63 is confined to a ring of basal-like cells surrounding, but at a distance from, centers of terminal differentiation. In less differentiated tumors, most cells contain p63 and their distribution is chaotic with respect to centers of terminal differentiation. p63 appears to be a valuable diagnostic marker for anaplastic keratinocytes.
Authors:
R Parsa; A Yang; F McKeon; H Green
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  113     ISSN:  0022-202X     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-01-13     Completed Date:  2000-01-13     Revised Date:  2008-06-27    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1099-105     Citation Subset:  IM    
Affiliation:
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
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MeSH Terms
Descriptor/Qualifier:
Carcinoma, Squamous Cell / chemistry
Cell Division
Cells, Cultured
DNA-Binding Proteins
Epidermis / chemistry
Genes, Tumor Suppressor
Hair Follicle / chemistry
Humans
Keratinocytes / physiology*
Ki-67 Antigen / analysis
Membrane Proteins*
Phosphoproteins / analysis,  genetics,  physiology*
RNA, Messenger / analysis
Skin Neoplasms / pathology*
Trans-Activators*
Tumor Suppressor Proteins
Chemical
Reg. No./Substance:
0/CKAP4 protein, human; 0/DNA-Binding Proteins; 0/Ki-67 Antigen; 0/Membrane Proteins; 0/Phosphoproteins; 0/RNA, Messenger; 0/TP63 protein, human; 0/Trans-Activators; 0/Tumor Suppressor Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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