Document Detail

Association of p63 with proliferative potential in normal and neoplastic human keratinocytes.
MedLine Citation:
PMID:  10594758     Owner:  NLM     Status:  MEDLINE    
p63, a recently identified member of the p53 gene family, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. We show that in normal human epidermis, in hair follicles, and in stratified epidermal cultures, p63 protein is principally restricted to cells with high proliferative potential and is absent from the cells that are undergoing terminal differentiation. In normal human epidermis and in hair follicles, basal cells with abundant p63 are interspersed with cells with little or no p63. Whenever p63 mRNA is present, it encodes mainly truncated, potentially dominant-negative isotypes. In squamous cell carcinomas, the number of cells containing p63 and their distribution depends on the degree of anaplasia. In highly differentiated tumors, p63 is confined to a ring of basal-like cells surrounding, but at a distance from, centers of terminal differentiation. In less differentiated tumors, most cells contain p63 and their distribution is chaotic with respect to centers of terminal differentiation. p63 appears to be a valuable diagnostic marker for anaplastic keratinocytes.
R Parsa; A Yang; F McKeon; H Green
Related Documents :
10561418 - Regional distribution of ionic currents and membrane voltage responses of type ii hair ...
17426438 - Constitutive autophagy in plant root cells.
16648588 - Multiple quantitative trait loci modify cochlear hair cell degeneration in the beethove...
9858718 - Distinct expression patterns of notch family receptors and ligands during development o...
21115388 - Redox active secondary metabolites.
16619238 - Acrolein-mediated mechanisms of neuronal death.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  113     ISSN:  0022-202X     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-01-13     Completed Date:  2000-01-13     Revised Date:  2008-06-27    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1099-105     Citation Subset:  IM    
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Carcinoma, Squamous Cell / chemistry
Cell Division
Cells, Cultured
DNA-Binding Proteins
Epidermis / chemistry
Genes, Tumor Suppressor
Hair Follicle / chemistry
Keratinocytes / physiology*
Ki-67 Antigen / analysis
Membrane Proteins*
Phosphoproteins / analysis,  genetics,  physiology*
RNA, Messenger / analysis
Skin Neoplasms / pathology*
Tumor Suppressor Proteins
Reg. No./Substance:
0/CKAP4 protein, human; 0/DNA-Binding Proteins; 0/Ki-67 Antigen; 0/Membrane Proteins; 0/Phosphoproteins; 0/RNA, Messenger; 0/TP63 protein, human; 0/Trans-Activators; 0/Tumor Suppressor Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The function of nitric oxide in wound repair: inhibition of inducible nitric oxide-synthase severely...
Next Document:  Barrier formation in the human fetus is patterned.