| Association of p53 codon 72 polymorphism with endometriosis. | |
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MedLine Citation:
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PMID: 17931634 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study the association of endometriosis with p53 codon 72 polymorphism in the population of central Italy and to search for possible interaction with the PTPN22 polymorphism. DESIGN: Study of p53 and PTPN22 polymorphisms in women with endometriosis. Analysis of PTPN22 genotype distribution in relation to p53 genotypes. SETTING: Department of Obstetrics and Gynecology of the University of Rome "Tor Vergata." PATIENT(S): The study included 129 women with endometriosis and 147 controls from the Caucasian population of central Italy. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Evaluation of risk for endometriosis. RESULT(S): No significant difference in the distribution of p53 codon 72 genotypes was observed between endometriosis patients and controls. An interaction between p53 and PTPN22 was observed: a protective action by the Arg/Arg genotype against endometriosis seems to be present only in carriers of the ( *)T allele of PTPN22. CONCLUSION(S): The negative association between the Arg/Arg genotype of p53 codon 72 found in Chinese people has not been observed in Japanese and Italian populations. Interaction with genes showing different allele frequencies among ethnic groups could be responsible for the differences reported among human populations concerning the relationship between p53 and susceptibility to endometriosis. |
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Authors:
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Maria Ammendola; Fulvia Gloria-Bottini; Francesco Sesti; Emilio Piccione; Egidio Bottini |
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Publication Detail:
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Type: Journal Article Date: 2007-10-10 |
Journal Detail:
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Title: Fertility and sterility Volume: 90 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-01 Completed Date: 2008-08-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 406-8 Citation Subset: IM |
Affiliation:
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Division of Obstetrics and Gynecology, Department of Surgery, University of Rome Tor Vergata, School of Medicine, Rome, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Codon Endometriosis / genetics* European Continental Ancestry Group / genetics Female Humans Infant, Newborn Italy Polymorphism, Genetic Protein Tyrosine Phosphatase, Non-Receptor Type 22 / genetics Tumor Suppressor Protein p53 / genetics* |
| Chemical | |
Reg. No./Substance:
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0/Codon; 0/Tumor Suppressor Protein p53; EC 3.1.3.48/PTPN22 protein, human; EC 3.1.3.48/Protein Tyrosine Phosphatase, Non-Receptor Type 22 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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