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Association of nox1 and vinculin with colon cancer progression.
MedLine Citation:
PMID:  23627409     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Nox1 mRNA, protein, and activities were compared in the paired primary and metastatic colon adenocarcinoma cell lines SW480 and SW620, and in normal colon tissues and colon cancer tissues. Our results demonstrated that Nox1 levels were higher in the primary SW480 cells than that in metastatic SW620 cells and were not associated with colon cancer progression. We further discovered that vinculin protein level in SW620 was much higher than that in SW480 cells, whereas E-cadherin was lower. We conclude that vinculin and E-cadherin, but not Nox1, may serve as biomarkers for colon cancer progression.
Authors:
Zheng Sun; Feng Liu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer investigation     Volume:  31     ISSN:  1532-4192     ISO Abbreviation:  Cancer Invest.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8307154     Medline TA:  Cancer Invest     Country:  England    
Other Details:
Languages:  eng     Pagination:  273-8     Citation Subset:  IM    
Affiliation:
Department of Gastrointestinal Surgery, Affiliated Guangzhou First Municipal People's Hospital, Guangzhou Medical College , Guangzhou 510180 , China,1.
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