Document Detail


Association of norepinephrine transporter gene with methylphenidate response.
MedLine Citation:
PMID:  15322419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: This study aimed to explore the association between alleles of the norepinephrine transporter gene and the methylphenidate response. METHOD: Chinese Han youths with attention-deficit/hyperactivity disorder recruited in the Outpatient Department of the Institute of Mental Health from 2001 to 2004 were treated with methylphenidate in doses of 0.45 to 0.60 mg/kg per day. Behavior changes were measured by the ADHD Rating Scale-IV when optimal doses were reached. The single-nucleotide polymorphic allele of norepinephrine transporter gene G1287A was used as the genetic marker, and the genotypes were identified by restriction fragment length polymorphism analysis. RESULTS: A significant association was found between norepinephrine transporter gene G1287A genotypes and response to methylphenidate for hyperactive-impulsive subscale scores (mean score reduction was 7.15 and 6.94 for G/G and G/A genotype, respectively, and 2.13 for A/A; p = .012) but not inattentive scores. CONCLUSIONS: These findings suggest an association between the G1287A polymorphism of the norepinephrine transporter gene and variation in methylphenidate response. Further work is needed to confirm this finding and to assess its generalization to other ethnic groups.
Authors:
Li Yang; Yu-Feng Wang; Jun Li; Stephen V Faraone
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Academy of Child and Adolescent Psychiatry     Volume:  43     ISSN:  0890-8567     ISO Abbreviation:  J Am Acad Child Adolesc Psychiatry     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-23     Completed Date:  2004-12-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8704565     Medline TA:  J Am Acad Child Adolesc Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1154-8     Citation Subset:  IM    
Copyright Information:
Copyright 2004 American Academy of Child and Adolescent Psychiatry
Affiliation:
Institute of Mental Health, Peking University, China.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Alleles*
Asian Continental Ancestry Group / genetics*,  psychology
Attention Deficit Disorder with Hyperactivity / diagnosis,  drug therapy*,  ethnology,  genetics*
Central Nervous System Stimulants / therapeutic use*
Child
China
Dose-Response Relationship, Drug
Female
Genetic Variation / genetics
Genotype*
Humans
Male
Methylphenidate / therapeutic use*
Personality Assessment
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide / genetics*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Central Nervous System Stimulants; 113-45-1/Methylphenidate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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