Document Detail

Association of nighttime hypertension with central arterial stiffness and urinary albumin excretion in dipper hypertensive subjects.
MedLine Citation:
PMID:  20962782     Owner:  NLM     Status:  In-Process    
Both blood pressure (BP) non-dipping and nighttime hypertension have been associated with accelerated target-organ damage (TOD). However, increased nighttime BP in subjects with a dipping circadian BP profile has never been reported or associated with TOD. Here, we investigated the relationships of nighttime BP with indices of vascular and kidney damage in dipper hypertensive subjects. We studied 402 subjects with untreated stage I-II essential hypertension. According to ambulatory BP recordings, 127 dipper subjects were selected and subdivided into nighttime hypertensives (NH, n = 69) (nighttime BP ≥ 120/70) and nighttime normotensives (NN, n = 50) (nighttime BP <120/70 mm Hg). All participants underwent echocardiographic examination and assessments of carotid-to-femoral pulse wave velocity (c-f PWV), albumin-to-creatinine ratio (ACR), metabolic profile and high sensitivity C-reactive protein (hs-CRP) level. Compared with NN dippers, NH dippers had higher c-f PWV (P < 0.001), ACR values (P = 0.01) and hs-CRP levels (P < 0.001). Multiple regression analysis showed that nighttime BP was more correlated with c-f PWV and ACR than was daytime BP. Among dippers, nighttime BP is associated more closely with c-f PWV and ACR than is daytime BP. These findings imply that even in dippers, absolute nighttime BP values should be taken into account when predicting surrogate end points such as arterial stiffness and urinary albumin excretion.
Dimitrios Syrseloudis; Costas Tsioufis; Ioannis Andrikou; Anastasia Mazaraki; Costas Thomopoulos; Costas Mihas; Theodoros Papaioannou; Iraklis Tatsis; Eleftherios Tsiamis; Christodoulos Stefanadis
Publication Detail:
Type:  Journal Article     Date:  2010-10-21
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  34     ISSN:  1348-4214     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  120-5     Citation Subset:  IM    
First Cardiology Clinic, University of Athens, Hippokration Hospital, Athens, Greece.
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