| Association of neonatal thrombocytopenia and maternal anti-HLA antibodies. | |
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MedLine Citation:
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PMID: 1853716 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to evaluate the influence of maternal anti-HLA antibody on neonatal thrombocytopenia, clinical features and maternal anti-HLA antibody of three groups of infants (19 thrombocytopenic and low birth weight, 27 nonthrombocytopenic and low birth weight, and 80 healthy full-term) were investigated. The incidence of positive maternal anti-HLA antibodies in the three groups was 73.7%, 29.6% and 27.5%, respectively. Thrombocytopenia in small-for-gestational-age (SGA) infants was closely related to the presence of maternal anti-HLA antibodies. Among 20 SGA infants (11 thrombocytopenic, 9 non-thrombocytopenic), anti-HLA antibody was detected in 10 mothers (90.9%) of thrombocytopenic SGA infants, while it was positive in only one mother (11.1%) of nonthrombocytopenic SGA infants. Investigation of the SGA infants revealed that in those whose mothers were sensitized to HLA antigen, not only the platelet count but also the leukocyte and lymphocyte counts in the first week of life were significantly lower than in infants whose mothers were not sensitized. The results suggest that the presence of maternal anti-HLA antibody is a cause of neonatal thrombocytopenia especially in SGA infants. |
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Authors:
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N Koyama; Y Ohama; K Kaneko; Y Itakura; T Nakamura; J Takasaki; T Tanaka; H Eguchi; A Kawase; K Kamiya |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta paediatrica Japonica; Overseas edition Volume: 33 ISSN: 0374-5600 ISO Abbreviation: Acta Paediatr Jpn Publication Date: 1991 Feb |
Date Detail:
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Created Date: 1991-08-22 Completed Date: 1991-08-22 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370357 Medline TA: Acta Paediatr Jpn Country: JAPAN |
Other Details:
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Languages: eng Pagination: 71-6 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Saitama Medical Center, Saitama Medical School, Kawagoe, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies
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blood* Blood Cell Count Female HLA Antigens / immunology* Humans Infant, Low Birth Weight Infant, Newborn Infant, Small for Gestational Age Maternal-Fetal Exchange / immunology Pregnancy / immunology Thrombocytopenia / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/HLA Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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