Document Detail

Association of the mu-opioid receptor gene with smoking cessation.
MedLine Citation:
PMID:  17224915     Owner:  NLM     Status:  MEDLINE    
We investigated the association of the OPRM1 genotype with long-term smoking cessation and change in body mass index (BMI) following a smoking cessation attempt among smokers who attempted to quit using the nicotine replacement therapy (NRT) patch or placebo in a randomized controlled trial, and were followed-up over an 8-year period following their initial cessation attempt. We also investigated possible sex differences in these relationships, given evidence for sex differences in smoking cessation and central opioid mechanisms, as well as some evidence for sex differences in response to NRT. Our results indicate that OPRM1 genotype may moderate the effect of transdermal nicotine patch compared to placebo during active treatment, with a benefit of active NRT treatment evident in the OPRM1 AA genotype group only and those carrying one or more copies of the G allele demonstrating no benefit of active NRT versus placebo patch. Our results also indicate a sex difference in change in BMI at 8-year follow-up following a smoking cessation attempt, with ex-smokers demonstrating an increase in BMI, and this increase being greater in female subjects than in male subjects. We did not observe any association of OPRM1 genotype with change in BMI, although there was a trend for genotype to influence the observed sex difference in change in BMI over time. Future studies should attempt to replicate these findings, and investigate the relationship between both short- and long-term weight gain and smoking cessation and investigate possible mechanisms that may underlie these processes. Future studies should also investigate the role of OPRM1 genotype and smoking cessation on other appetitive and reward behaviours such as alcohol consumption.
M R Munafò; K M Elliot; M F G Murphy; R T Walton; E C Johnstone
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2007-01-16
Journal Detail:
Title:  The pharmacogenomics journal     Volume:  7     ISSN:  1470-269X     ISO Abbreviation:  Pharmacogenomics J.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-26     Completed Date:  2007-11-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101083949     Medline TA:  Pharmacogenomics J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  353-61     Citation Subset:  IM    
Department of Experimental Psychology, University of Bristol, Bristol, UK.
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MeSH Terms
Administration, Cutaneous
Body Mass Index
Double-Blind Method
Follow-Up Studies
Gene Frequency
Logistic Models
Middle Aged
Nicotine / administration & dosage*
Nicotinic Agonists / administration & dosage*
Odds Ratio
Receptors, Opioid, mu / genetics*
Sex Factors
Smoking / drug therapy*,  genetics*,  physiopathology
Smoking Cessation*
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Nicotinic Agonists; 0/OPRM1 protein, human; 0/Receptors, Opioid, mu; 54-11-5/Nicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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