Document Detail

Association of a microsomal triglyceride transfer protein gene polymorphism with blood pressure in Japanese women.
MedLine Citation:
PMID:  16328015     Owner:  NLM     Status:  MEDLINE    
Genetic variants of the microsomal triglyceride transfer protein (MTP) have been associated with the serum concentration of low density lipoprotein-cholesterol, predisposition to coronary heart disease, or longevity. The relation of a -493Gright curved arrow T polymorphism in the promoter of MTP to blood pressure was examined in a population-based study. The subjects (1124 men, 1108 women) were aged 40-79 years and were randomly recruited to a population-based prospective cohort study of aging and age-related diseases in Japan. Blood pressure was measured at least twice with subjects in the sitting position. The serum lipid profile was determined after the subjects had fasted overnight. The -493Gright curved arrow T genotype of MTP was determined with a fluorescence-based allele-specific DNA primer assay system. There was no difference in the serum concentrations of total cholesterol, high density lipoprotein-cholesterol, low density lipoprotein-cholesterol, or triglycerides among MTP genotypes for men or for women. Systolic or diastolic blood pressure was not related to the -493Gright curved arrow T polymorphism in men. For women, however, systolic and diastolic blood pressures were significantly related to MTP genotype, with the T allele of the polymorphism being associated with low blood pressure. The relation between MTP genotype and the prevalence of hypertension was almost significant (P=0.055) for all women. Although MTP genotype was not associated with the prevalence of hypertension in premenopausal women, the relation between these parameters was significant (P=0.040) in postmenopausal women, with the TT genotype protecting against this condition. These results suggest that MTP genotype is a determinant of blood pressure in Japanese women.
Yoshiji Yamada; Fujiko Ando; Hiroshi Shimokata
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of molecular medicine     Volume:  17     ISSN:  1107-3756     ISO Abbreviation:  Int. J. Mol. Med.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-05     Completed Date:  2006-03-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9810955     Medline TA:  Int J Mol Med     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  83-8     Citation Subset:  IM    
Department of Human Functional Genomics, Life Science Research Center, Mie University, Mie 514-8507, Japan.
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MeSH Terms
Asian Continental Ancestry Group / genetics
Blood Pressure / genetics*,  physiology
Carrier Proteins / genetics*
Hypertension / metabolism
Lipids / blood
Middle Aged
Polymorphism, Genetic*
Promoter Regions, Genetic*
Random Allocation
Reg. No./Substance:
0/Carrier Proteins; 0/Lipids; 0/microsomal triglyceride transfer protein

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