Document Detail

Association of microsomal epoxide hydrolase gene polymorphism and pre-eclampsia in Turkish women.
MedLine Citation:
PMID:  17212663     Owner:  NLM     Status:  MEDLINE    
AIM: To assess the association between human epoxide hydrolase exon 3 and 4 polymorphisms and pre-eclampsia by carrying out a case-control study in Turkish women. METHODS: DNA was extracted from peripheral blood leukocytes, and genotype distribution of exon 3 and exon 4 of epoxide hydrolase gene (EPHX) was carried out in 271 patients and 155 controls. RESULTS: There was no statistically significant difference in the distribution of genotypes between pre-eclampsia without HELLP and pre-eclampsia plus HELLP cases and controls for the exon 3 and 4 polymorphism of EPHX. However, we found a significant association between the predicted enzyme activity level and pre-eclampsia (P = 0.018). The distribution of subjects with predicted high, intermediate and low microsomal epoxide hydrolase enzyme (EPHX) activity were 23.2, 38.8 and 38% in cases and 12, 47.3 and 40.7% in controls, respectively. CONCLUSION: Although we could not find any association between genetic variability in exon 3 and 4 of EPHX and pre-eclampsia, genetic variability in these two exons jointly modifies the predicted enzyme activity and may be a risk factor for pre-eclampsia.
Ergun Pinarbasi; Ferda E Percin; Meral Yilmaz; Egemen Akgun; Meral Cetin; Ali Cetin
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  33     ISSN:  1341-8076     ISO Abbreviation:  J. Obstet. Gynaecol. Res.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-10     Completed Date:  2007-05-08     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  32-7     Citation Subset:  IM    
Department of Medical Biology, Cumhuriyet University, School of Medicine, Sivas, Turkey.
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MeSH Terms
Case-Control Studies
Epoxide Hydrolases / genetics*
Genetic Predisposition to Disease
HELLP Syndrome / genetics
Middle Aged
Polymorphism, Genetic*
Pre-Eclampsia / genetics*
Reg. No./Substance:
EC 3.3.2.-/Epoxide Hydrolases

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