| Association of microsomal epoxide hydrolase gene polymorphism and pre-eclampsia in Turkish women. | |
| | |
MedLine Citation:
|
PMID: 17212663 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIM: To assess the association between human epoxide hydrolase exon 3 and 4 polymorphisms and pre-eclampsia by carrying out a case-control study in Turkish women. METHODS: DNA was extracted from peripheral blood leukocytes, and genotype distribution of exon 3 and exon 4 of epoxide hydrolase gene (EPHX) was carried out in 271 patients and 155 controls. RESULTS: There was no statistically significant difference in the distribution of genotypes between pre-eclampsia without HELLP and pre-eclampsia plus HELLP cases and controls for the exon 3 and 4 polymorphism of EPHX. However, we found a significant association between the predicted enzyme activity level and pre-eclampsia (P = 0.018). The distribution of subjects with predicted high, intermediate and low microsomal epoxide hydrolase enzyme (EPHX) activity were 23.2, 38.8 and 38% in cases and 12, 47.3 and 40.7% in controls, respectively. CONCLUSION: Although we could not find any association between genetic variability in exon 3 and 4 of EPHX and pre-eclampsia, genetic variability in these two exons jointly modifies the predicted enzyme activity and may be a risk factor for pre-eclampsia. |
| | |
Authors:
|
Ergun Pinarbasi; Ferda E Percin; Meral Yilmaz; Egemen Akgun; Meral Cetin; Ali Cetin |
Related Documents
:
|
1362943 - Studies on tertiary amine udp-glucuronosyltransferases from human and rabbit hepatic mi... 22061103 - Simple test for differentiation between fresh pork and frozen/thawed pork. 1644853 - Vitamin d hydroxylases. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The journal of obstetrics and gynaecology research Volume: 33 ISSN: 1341-8076 ISO Abbreviation: J. Obstet. Gynaecol. Res. Publication Date: 2007 Feb |
Date Detail:
|
Created Date: 2007-01-10 Completed Date: 2007-05-08 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 9612761 Medline TA: J Obstet Gynaecol Res Country: Japan |
Other Details:
|
Languages: eng Pagination: 32-7 Citation Subset: IM |
Affiliation:
|
Department of Medical Biology, Cumhuriyet University, School of Medicine, Sivas, Turkey. epinar@cumhuriyet.edu.tr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Case-Control Studies Epoxide Hydrolases / genetics* Female Genetic Predisposition to Disease HELLP Syndrome / genetics Humans Middle Aged Polymorphism, Genetic* Pre-Eclampsia / genetics* Pregnancy Turkey |
| Chemical | |
Reg. No./Substance:
|
EC 3.3.2.-/Epoxide Hydrolases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Allogeneic and autologous ovarian orthotopic transplantation without a vascular pedicle: morphologic...
Next Document: Interleukin-8 and glucose in amniotic fluid, fetal fibronectin in vaginal secretions and preterm lab...