| Association of methionine synthase and thymidylate synthase genetic polymorphisms with idiopathic recurrent pregnancy loss. | |
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MedLine Citation:
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PMID: 23415967 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the association between one-carbon metabolism and recurrent pregnancy loss (RPL). One-carbon metabolism is important for maintaining pregnancy, and the enzymes codified by these genes are relevant to this metabolic pathway. DESIGN: Case-control study. SETTING: An urban university-based hospital in South Korea. PATIENT(S): A cohort of 353 RPL patients (3.09 ± 1.65 pregnancy losses) and 226 control subjects. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Genotyping was assessed by polymerase chain reaction-restriction fragment length polymorphism assay. We examined polymorphisms in four genes: methionine synthase (MTR); methionine synthase reductase (MTRR); methylenetetrahydrofolate dehydrogenase 1 (MTHFD1); and thymidylate synthase (TS). RESULT(S): The MTR 2756AA polymorphism was associated with RPL. Gene-gene interaction analysis revealed that the frequency of the MTR 2756A-TS 6-bp allele combination was significantly higher in RPL. CONCLUSION(S): Based on these results, we propose that the MTR 2756AA genotype and MTR 2756A-TS 6-bp allele combination are possible predisposing factors for RPL development in Korean women. |
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Authors:
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Ji Hyang Kim; Young Joo Jeon; Bo Eun Lee; Hojeong Kang; Ji Eun Shin; Dong Hee Choi; Woo Sik Lee; Nam Keun Kim |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-2-14 |
Journal Detail:
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Title: Fertility and sterility Volume: - ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-2-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Obstetrics and Gynecology, CHA Bundang Medical Center, School of Medicine, CHA University, Seongnam, South Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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