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Association of methionine synthase and thymidylate synthase genetic polymorphisms with idiopathic recurrent pregnancy loss.
MedLine Citation:
PMID:  23415967     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the association between one-carbon metabolism and recurrent pregnancy loss (RPL). One-carbon metabolism is important for maintaining pregnancy, and the enzymes codified by these genes are relevant to this metabolic pathway. DESIGN: Case-control study. SETTING: An urban university-based hospital in South Korea. PATIENT(S): A cohort of 353 RPL patients (3.09 ± 1.65 pregnancy losses) and 226 control subjects. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Genotyping was assessed by polymerase chain reaction-restriction fragment length polymorphism assay. We examined polymorphisms in four genes: methionine synthase (MTR); methionine synthase reductase (MTRR); methylenetetrahydrofolate dehydrogenase 1 (MTHFD1); and thymidylate synthase (TS). RESULT(S): The MTR 2756AA polymorphism was associated with RPL. Gene-gene interaction analysis revealed that the frequency of the MTR 2756A-TS 6-bp allele combination was significantly higher in RPL. CONCLUSION(S): Based on these results, we propose that the MTR 2756AA genotype and MTR 2756A-TS 6-bp allele combination are possible predisposing factors for RPL development in Korean women.
Authors:
Ji Hyang Kim; Young Joo Jeon; Bo Eun Lee; Hojeong Kang; Ji Eun Shin; Dong Hee Choi; Woo Sik Lee; Nam Keun Kim
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-14
Journal Detail:
Title:  Fertility and sterility     Volume:  -     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Obstetrics and Gynecology, CHA Bundang Medical Center, School of Medicine, CHA University, Seongnam, South Korea.
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