| Association of medication and the human plasma <i>N</i>-glycans. | |
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MedLine Citation:
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PMID: 22256781 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Glycosylation is highly variable depending on many environmental factors. Using our fully quantitative high-throughput normal phase hydrophilic interaction liquid chromatography we have identified glycosylation changes associated with medication in the plasma <i>N</i>-glycome from three different population cohorts: ORCADES from the Orkney Islands in Scotland and CROATIA-Vis and CROATIA-Korcula from the Croatian islands of Vis and Korcula. Associations between glycosylation and the use of hormones (oral contraceptives, hormone replacement therapy), non-steroidal anti-inflammatory drugs (aspirin and other NSAIDs), oral steroids (prednisolone) and steroid inhalers (beclomethasone) were investigated. Significant differences associated with usage of oral contraceptives were found with increased core-fucosylated biantennary glycans. Decreases in core-fucosylated biantennary glycans, core-fucosylated triantennary glycans with outer-arm fucose and high mannosylated glycans were associated with the use of anti-inflammatory drugs. All the changes in glycosylation were independent of blood group status. In conclusion, hormones and anti-inflammatory medication were associated with changes in glycosylation, possibly as a result of the modulatory effect of the inflammatory response. In general, cancer is associated with inflammation and many glycoproteins in the serum are acute phase related to the host response. These preliminary data indicate the importance of correcting levels of glycans used as biomarkers for the effect of medication. |
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Authors:
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Radka Saldova; Jennifer E Huffman; Barbara Adamczyk; Ana Muzinic; Jayesh J Kattla; Maja Pučić; Mislav Novokmet; Jodie L Abrahams; Caroline Hayward; Igor Rudan; Sarah Wild; Alan Wright; Ozren Polasek; Gordan Lauc; Harry Campbell; James F Wilson; Pauline Mary Rudd |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-18 |
Journal Detail:
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Title: Journal of proteome research Volume: - ISSN: 1535-3907 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101128775 Medline TA: J Proteome Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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