Document Detail

Association of maternal hematocrit with premature labor.
MedLine Citation:
PMID:  3394728     Owner:  NLM     Status:  MEDLINE    
An examination of the association of maternal hematocrit with the occurrence of premature birth revealed a continuous relationship between these two factors with an increasing rate of prematurity occurring with decreasing maternal hematocrit. The lowest risk of premature birth was found when maternal hematocrit was between 41% and 44%. Statistically increases in prematurity were noted at all hematocrit levels of less than or equal to 38%. A woman with a hematocrit of 37% had twice the risk of having a premature birth as a woman whose hematocrit was between 41% and 44% (p less than 0.01). In a logistic regression analysis with premature birth as the dependent variable and hematocrit as the only predictor variable, it was noted that decreasing the hematocrit by a single point was associated with a 24% increase in the risk of prematurity (odds ratio = 1.24) while a five-point decrease in hematocrit was associated with a tripling in the risk of prematurity (odds ratio = 2.98). In a multivariable logistic regression analysis hematocrit was noted to explain more of the variation in prematurity than any of the other risk factors included in the model. An investigation of this association in specific groups at high risk of having premature births revealed that 46% of the increased risk of prematurity in black women and 49% of the increased risk of prematurity in women receiving welfare was related to hematocrit or some factor associated with hematocrit.
E Lieberman; K J Ryan; R R Monson; S C Schoenbaum
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  159     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1988-08-19     Completed Date:  1988-08-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  107-14     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
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MeSH Terms
African Continental Ancestry Group
Anemia / complications
Obstetric Labor, Premature / blood*,  etiology
Predictive Value of Tests
Regression Analysis
Risk Factors
Socioeconomic Factors
Grant Support
Comment In:
Am J Obstet Gynecol. 1989 Dec;161(6 Pt 1):1750-1   [PMID:  2631724 ]
Am J Obstet Gynecol. 1990 Jan;162(1):293-5   [PMID:  2301506 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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