| Association of maternal fat and alcohol intake with maternal and umbilical hormone levels and birth weight. | |
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MedLine Citation:
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PMID: 17428259 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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High levels of estrogen during pregnancy have been hypothesized to increase the risk of breast cancer in offspring. Some studies have reported a positive association of estrogen level during pregnancy with fetal size, which has been linked to the subsequent risk of breast cancer in offspring. We examined whether maternal diet, including fat and alcohol intake, was associated with hormone levels during pregnancy, as well as with birth weight. The concentrations of estradiol, estriol, and testosterone were measured in the maternal serum and umbilical cord blood of 189 women during pregnancy and at delivery. Intakes of fat, alcohol, and other nutrients were assessed by 5-day diet records at approximately the 29th week of pregnancy before blood sampling. Intake of polyunsaturated fatty acids was moderately but significantly positively correlated with the umbilical cord estriol level (r = 0.17, P = 0.03) after controlling for covariates. The positive association between intake of polyunsaturated fatty acids and birth weight was of borderline significance (r = 0.14, P = 0.06). Intake of long-chain n-3 fatty acids was significantly inversely correlated with the umbilical cord estradiol and testosterone levels (r = -0.18, P = 0.02 and r = -0.24, P = 0.002, respectively). Alcohol intake was significantly positively correlated with the maternal estradiol level in the 29th week of pregnancy (r = 0.19, P = 0.01), but was unrelated to birth weight. Estrogen level during pregnancy may be regulated by dietary polyunsaturated fatty acids and mediate their effects on fetal growth. |
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Authors:
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Chisato Nagata; Shinichi Iwasa; Makoto Shiraki; Yukari Sahashi; Hiroyuki Shimizu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-04-12 |
Journal Detail:
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Title: Cancer science Volume: 98 ISSN: 1347-9032 ISO Abbreviation: Cancer Sci. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-05-01 Completed Date: 2007-08-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101168776 Medline TA: Cancer Sci Country: England |
Other Details:
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Languages: eng Pagination: 869-73 Citation Subset: IM |
Affiliation:
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Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido Gifu 500-8058, Japan. chisato@gifu-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Drinking* Birth Weight* Dietary Fats* Estradiol / blood Estrogens / blood Fatty Acids, Unsaturated Female Fetal Blood / chemistry* Gonadal Steroid Hormones / blood* Humans Mothers Pregnancy Testosterone / blood* |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Estrogens; 0/Fatty Acids, Unsaturated; 0/Gonadal Steroid Hormones; 50-28-2/Estradiol; 58-22-0/Testosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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