Document Detail

Association of maternal IL-1 receptor antagonist intron 2 gene polymorphism and preterm birth.
MedLine Citation:
PMID:  17074546     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study was undertaken to determine whether the interleukin-1 receptor antagonist (IL-1RN) variable number tandem repeat polymorphism is associated with preterm birth. STUDY DESIGN: A case-control study was performed. Cases (n = 95) delivered before 37 weeks after preterm labor (PTL) or preterm premature rupture of membranes (PPROM) and controls (n = 105) delivered after 37 weeks. Maternal DNA was genotyped by polymerase chain reaction for a length polymorphism in intron 2 of the IL-1RN gene. RESULTS: There was no significant difference in maternal age, ethnicity, insurance status, or parity between groups. Allele and genotype frequencies did not differ significantly from that expected under Hardy-Weinberg equilibrium (P = .59) in the total group as well as study groups. Of the 95 cases, 26.8% had at least 1 copy of allele 2 present compared with 12.4% in the control group (P < .0004). CONCLUSION: Maternal carriage of at least 1 copy of the IL-1RN allele 2 appears to be associated with increased risk of preterm birth.
Amy P Murtha; Angel Nieves; Elizabeth R Hauser; Geeta K Swamy; Bryan A Yonish; Tammy R Sinclair; R Phillips Heine
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  195     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-31     Completed Date:  2006-12-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1249-53     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Duke University Medical Center, Durham, NC, USA.
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MeSH Terms
Case-Control Studies
Gene Dosage
Gene Frequency
Genetic Predisposition to Disease*
Interleukin 1 Receptor Antagonist Protein / genetics*
Introns / genetics*
Polymorphism, Genetic*
Pregnancy / genetics*
Premature Birth / genetics*
Tandem Repeat Sequences
Reg. No./Substance:
0/IL1RN protein, human; 0/Interleukin 1 Receptor Antagonist Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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