Document Detail


Association of a maternal CD14 -159 gene polymorphism with preterm premature rupture of membranes and spontaneous preterm birth in multi-fetal pregnancies.
MedLine Citation:
PMID:  16427140     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CD14, the major receptor for bacterial lipopolysaccharide (LPS) as well as other microbial antigens, is a component of the innate immune system. We hypothesized that a single nucleotide C>T polymorphism at position -159 in the CD14 gene that results in elevated CD14 production would influence susceptibility to preterm premature rupture of membranes (PPROM) and spontaneous preterm birth (SPTB) in multi-fetal pregnancies. DNA from 107 mother-twin and three mother-triplet pairs was analyzed. Pregnancy outcomes were obtained after completion of testing. CD14*T homozygosity was present in 39.3% of 28 women whose pregnancies ended with PPROM, as opposed to 18.1% of 72 pregnancies without a SPTB (P=0.03). There was no relation between the fetal CD14 genotype and PPROM. The likelihood ratio (LR) for PPROM was 2.2 for women homozygous for CD14*T. The LR increased to 3.3 and 3.6 if the CD14 polymorphism was present in combination with previously determined maternal polymorphisms in the genes coding for the inducible 70kDa heat shock protein (hsp70-2) and the interleukin-1 receptor antagonist (IL1RN), respectively. Thus, an enhanced maternal pro-inflammatory immune response to LPS may increase susceptibility to PPROM in multi-fetal pregnancies.
Authors:
Robin B Kalish; Santosh Vardhana; Neil J Normand; Meruka Gupta; Steven S Witkin
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2006-01-19
Journal Detail:
Title:  Journal of reproductive immunology     Volume:  70     ISSN:  0165-0378     ISO Abbreviation:  J. Reprod. Immunol.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-15     Completed Date:  2006-08-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8001906     Medline TA:  J Reprod Immunol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  109-17     Citation Subset:  IM    
Affiliation:
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY, USA.
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MeSH Terms
Descriptor/Qualifier:
Antigens, CD14 / genetics*
Female
Fetal Membranes, Premature Rupture / genetics*
Genetic Predisposition to Disease
Humans
Interleukin 1 Receptor Antagonist Protein
Polymorphism, Genetic
Pregnancy
Pregnancy, Multiple / genetics*
Premature Birth / genetics*
Sialoglycoproteins / genetics
Grant Support
ID/Acronym/Agency:
HD 41676/HD/NICHD NIH HHS; M01 RR00047/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD14; 0/IL1RN protein, human; 0/Interleukin 1 Receptor Antagonist Protein; 0/Sialoglycoproteins

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