Document Detail

Association of mast cells with tumor angiogenesis in esophageal squamous cell carcinoma.
MedLine Citation:
PMID:  11553224     Owner:  NLM     Status:  MEDLINE    
The association of mast cells with tumor angiogenesis was investigated in patients with esophageal squamous cell carcinoma. Surgical specimens from 48 patients with esophageal squamous cell carcinoma were studied. Mast cells in tumor sections were stained with Alcian blue and safranin O. The number of mast cells was counted under light microscopy and the average count recorded. To highlight the microvessels, endothelial cells were stained with anti-human factor VIII antibody. Microvessel density was also counted. We found a significant correlation between mast cell count and microvessel density in patients with esophageal squamous cell carcinoma. Double staining of the microvessels revealed highly angiogenic areas densely populated with mast cells. There appears to be a direct correlation between the number of mast cells and tumor angiogenesis in patients with esophageal squamous cell carcinoma.
M Tomita; Y Matsuzaki; M Edagawa; T Shimizu; M Hara; R Sekiya; T Onitsuka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus / I.S.D.E     Volume:  14     ISSN:  1120-8694     ISO Abbreviation:  Dis. Esophagus     Publication Date:  2001  
Date Detail:
Created Date:  2001-09-12     Completed Date:  2001-12-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8809160     Medline TA:  Dis Esophagus     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  135-8     Citation Subset:  IM    
Department of Surgery II, Miyazaki Medical College, Kiyotake, Miyazaki, Japan.
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MeSH Terms
Aged, 80 and over
Carcinoma, Squamous Cell / pathology*
Cell Count
Esophageal Neoplasms / pathology*
Esophagus / blood supply
Mast Cells / cytology*,  pathology
Middle Aged
Neovascularization, Pathologic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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