Document Detail


Association of magnesium deficiency with the blood pressure-lowering effects of calcium.
MedLine Citation:
PMID:  2160489     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The role of dietary calcium and magnesium in the development of hypertension was studied in nine groups, each consisting of nine spontaneously hypertensive rats aged 8-31 weeks. The animals were fed AIN 76A semi-purified diets varying in calcium (0.075, 0.5 and 2.5%) and magnesium (0.01, 0.05 and 0.75%) concentrations according to a 3 x 3 factorial design. Dietary calcium and systolic blood pressure were inversely related, significantly (P less than 0.05) after 12 weeks. Total and ultrafilterable serum calcium concentrations were also significantly negatively correlated with blood pressure (r = -0.46; P = 0.001 and r = -0.57; P = 0.001, respectively). Repeated measures analysis of variance indicated that dietary magnesium had no effect on systolic blood pressure, and no calcium x magnesium interaction on blood pressure was observed. Signs of magnesium deficiency, calcium deposits in the kidneys, and histological lesions were observed in groups on a high-calcium diet receiving normal and low levels of magnesium. Thus a lowering of blood pressure by calcium supplementation, without concomitant magnesium supplementation, was accompanied by biochemical and histological abnormalities in this animal model.
Authors:
G H Evans; C M Weaver; D D Harrington; C F Babbs
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  8     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-06-27     Completed Date:  1990-06-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  327-37     Citation Subset:  IM    
Affiliation:
Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects*
Calcium, Dietary / adverse effects,  pharmacology*
Diet
Hypertension / diet therapy,  etiology
Kidney / drug effects,  pathology
Magnesium / pharmacology*
Magnesium Deficiency / physiopathology
Male
Rats
Rats, Inbred SHR
Chemical
Reg. No./Substance:
0/Calcium, Dietary; 7439-95-4/Magnesium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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