Document Detail

Association of macular pigment density with plasma ω-3 fatty acids: the PIMAVOSA study.
MedLine Citation:
PMID:  22273721     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To assess the correlation between macular pigment optical density and plasma levels of lutein, zeaxanthin, and fatty acids, especially omega-3 polyunsaturated fatty acids (PUFAs).
METHODS: The PIMAVOSA study is an observational study of 107 healthy volunteers, aged 20 to 60 years and born in southwest France, without histories of ocular disease. Macular pigment optical density (MPOD) was measured using the two-wavelength autofluorescence method with a modified scanning laser ophthalmoscope. Plasma measurements (lutein, zeaxanthin, and fatty acids) were performed from fasting blood samples collected on the day of the eye examination.
RESULTS: MPOD within 6° correlated with plasma levels of lutein and zeaxanthin (r = 0.35, P < 0.001, and r = 0.30, P < 0.005, respectively). MPOD also significantly correlated with total plasma omega-3 PUFAs (r = 0.22, P < 0.05). Among the different omega-3 PUFAs, docosapentaenoic acid (DPA) had the highest correlation with MPOD (r = 0.31, P < 0.001), whereas correlation with eicosapentaenoic acid (EPA) was moderate (r = 0.21, P < 0.05) and did not reach statistical significance for docosahexaenoic acid (r = 0.14, P = 0.14).
CONCLUSIONS: In the present study, macular pigment density was associated not only with plasma lutein and zeaxanthin but also with omega-3 long-chain PUFAs, particularly with EPA and DPA. Further studies will be needed to confirm these findings and to identify the underlying mechanisms.
Marie-Noëlle Delyfer; Benjamin Buaud; Jean-François Korobelnik; Marie-Bénédicte Rougier; Wolfgang Schalch; Stephane Etheve; Carole Vaysse; Nicole Combe; Mélanie Le Goff; Ute E K Wolf-Schnurrbusch; Sebastian Wolf; Pascale Barberger-Gateau; Cécile Delcourt
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-03-09
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  53     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-12     Completed Date:  2012-05-08     Revised Date:  2013-01-09    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1204-10     Citation Subset:  IM    
University of Bordeaux Segalen, Bordeaux, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biological Markers / blood
Fatty Acids, Omega-3 / blood*
Follow-Up Studies
Macula Lutea / cytology*
Macular Degeneration / blood,  pathology
Middle Aged
Reference Values
Retinal Pigment Epithelium / cytology*
Young Adult
Reg. No./Substance:
0/Biological Markers; 0/Fatty Acids, Omega-3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Impact of Epstein-Barr virus donor and recipient serostatus on the incidence of post-transplant lymp...
Next Document:  Alterations in the biomolecular signatures of developing chick corneas as determined by biospectrosc...