Document Detail


Association of macrophage migration inhibitory factor (MIF) polymorphisms with risk of meningitis from Streptococcus pneumoniae.
MedLine Citation:
PMID:  21208809     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Macrophage migration inhibitory factor (MIF) is an upstream proinflammatory cytokine encoded by a functionally polymorphic locus. This study of 119 patients explored the potential relationship between MIF genotype and invasive Streptococcus pneumoniae infections. We observed an association between a high-expression MIF allele and occurrence of pneumococcal meningitis.
Authors:
Sarah Doernberg; Bernhard Schaaf; Klaus Dalhoff; Lin Leng; Anna Beitin; Vincent Quagliarello; Richard Bucala
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural     Date:  2011-01-03
Journal Detail:
Title:  Cytokine     Volume:  53     ISSN:  1096-0023     ISO Abbreviation:  Cytokine     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-04     Completed Date:  2011-07-22     Revised Date:  2014-09-10    
Medline Journal Info:
Nlm Unique ID:  9005353     Medline TA:  Cytokine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  292-4     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Alleles
Female
Gene Frequency
Genetic Predisposition to Disease / genetics*
Genotype
Humans
Macrophage Migration-Inhibitory Factors / genetics*
Male
Meningitis, Pneumococcal / genetics*,  microbiology
Middle Aged
Polymorphism, Single Nucleotide*
Promoter Regions, Genetic / genetics
Risk Factors
Sequence Analysis, DNA
Young Adult
Grant Support
ID/Acronym/Agency:
R01 AI042310/AI/NIAID NIH HHS; R01 AI042310-02/AI/NIAID NIH HHS; R01 AI042310-03/AI/NIAID NIH HHS; R01 AI042310-04/AI/NIAID NIH HHS; R01 AI042310-05/AI/NIAID NIH HHS; R01 AI042310-06/AI/NIAID NIH HHS; R01 AI042310-07/AI/NIAID NIH HHS; R01 AI042310-08/AI/NIAID NIH HHS; R01 AI042310-09/AI/NIAID NIH HHS; R01 AI042310-10/AI/NIAID NIH HHS; R01 AI042310-11/AI/NIAID NIH HHS; R01 AI042310-12A1/AI/NIAID NIH HHS; R01 AI042310-13/AI/NIAID NIH HHS; R01 AI042310-14/AI/NIAID NIH HHS; R01-AI042310/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Macrophage Migration-Inhibitory Factors
Comments/Corrections

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