Document Detail

Association of lymphangioleiomyomatosis (LAM) with endosalpingiosis in the retroperitoneal lymph nodes: report of two cases.
MedLine Citation:
PMID:  11484504     Owner:  NLM     Status:  MEDLINE    
We report 2 patients in whom pulmonary lymphangioleiomyomatosis (LAM) affected the retroperitoneal lymph nodes and was associated with endosalpingiosis. These lesions were large, encapsulated masses with multiple cysts containing chylous fluid. Both were characterized by proliferating LAM cells that formed fascicles separated by slit-like channels. Some cysts were lined by ciliated epithelium resembling that of Fallopian tubes. Other cysts were lined either by flattened endothelial cells or by a mixture of these cells and epithelial cells. Many LAM cells gave a positive reaction with HMB-45 antibody. Most LAM cells in fascicles were reactive for alpha-smooth muscle actin and desmin. In 1 patient, many of the epithelial cells and some of the subjacent LAM cells were positive for estrogen and progesterone receptors. In conclusion, immunostaining with HMB-45 antibody and markers for smooth muscle cells can be helpful in the evaluation of problems in the differential diagnosis of lesions of extrapulmonary LAM, particularly those involving the genital system.
K Matsui; W D Travis; R Gonzalez; J A Terzian; J Rosai; J Moss; V J Ferrans
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International journal of surgical pathology     Volume:  9     ISSN:  1066-8969     ISO Abbreviation:  Int. J. Surg. Pathol.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-08-03     Completed Date:  2001-12-28     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9314927     Medline TA:  Int J Surg Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  155-62     Citation Subset:  IM    
Pathology Section, National Heart, Lung and Blood Institute, Bldg. 10/2N240, National Institutes of Health, 10 Center Dr. MSC-1518, Bethesda, MD 20892-1518, USA.
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MeSH Terms
Lymph Nodes / pathology*,  surgery*
Lymphangioleiomyomatosis / pathology*,  surgery*
Middle Aged
Retroperitoneal Space / pathology*
Salpingitis / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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