Document Detail


Association of lower eosinophil-related T helper 2 (Th2) cytokines with coronary artery lesions in Kawasaki disease.
MedLine Citation:
PMID:  19438983     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Kawasaki disease (KD) is a systemic febrile vasculitis particular coronary artery involvement. Eosinophilia has been found in our and other studies in KD. This study further investigates whether eosinophil-related T helper 2 (Th2) cytokines or the activation marker (eosinophil cationic protein - ECP) is involved in KD with coronary artery lesions (CAL). A total of 95 KD patients were enrolled for this study. Plasma samples were subjected to the measurement of interleukin (IL)-4, IL-5, and eotaxin by Luminex-Bedalyte multiplex beadmates system and to the measurement of ECP by fluoroimmunoassay. Patients with KD had higher eosinophils than controls. Eosinophil-related mediators: IL-4, IL-5, eotaxin, and ECP levels were also higher in KD patients than controls before intravenous immunoglobulin (IVIG) treatment. After IVIG treatment, ECP decreased but IL-4, IL-5, and eotaxin increased significantly. The higher the IL-5 and eosinophil levels after IVIG treatment, the lower rate of CAL was found. Changes of eosinophils after IVIG treatment were positively correlated to changes of IL-5 levels but not ECP levels. An increase of eosinophils and IL-5, but not ECP levels after IVIG treatment, was inversely correlated with CAL formation in KD.
Authors:
Ho-Chang Kuo; Chih-Lu Wang; Chi-Di Liang; Hong-Ren Yu; Chien-Fu Huang; Lin Wang; Kao-Pin Hwang; Kuender D Yang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology     Volume:  20     ISSN:  1399-3038     ISO Abbreviation:  Pediatr Allergy Immunol     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-14     Completed Date:  2009-06-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9106718     Medline TA:  Pediatr Allergy Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  266-72     Citation Subset:  IM    
Affiliation:
Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Blood Cell Count
Coronary Artery Disease / blood,  complications,  immunology*
Eosinophil Cationic Protein / blood
Eosinophils / immunology*,  metabolism
Female
Humans
Immunoglobulins, Intravenous / immunology,  therapeutic use
Interleukin-4 / blood
Interleukin-5 / blood
Male
Mucocutaneous Lymph Node Syndrome / blood,  complications,  drug therapy,  immunology*
Th2 Cells / immunology*,  metabolism
Young Adult
Chemical
Reg. No./Substance:
0/Immunoglobulins, Intravenous; 0/Interleukin-5; 207137-56-2/Interleukin-4; EC 3.1.27.-/Eosinophil Cationic Protein

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