Document Detail


Association and linkage studies between bipolar affective disorder and the polymorphic CAG/CTG repeat loci ERDA1, SEF2-1B, MAB21L and KCNN3.
MedLine Citation:
PMID:  11526470     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several reports have suggested the presence of anticipation in bipolar affective disorder (BPAD). In addition, independent studies using the RED (repeat expansion detection) have shown association between BPAD and longer CAG/CTG repeats. Therefore loci with large CAG/CTG repeats are plausible candidates in the inheritance of BPAD. The present study assesses the length of the repeats in four loci: the ERDA-1 locus which is known to account for most of the long CAG repeats detected by RED, the SEF2-1b locus which is placed in a region where positive linkage results have been reported and the loci MAB21L and KCNN3 as functional candidate genes. A Brazilian case-control sample with 115 unrelated BPAD patients and 196 healthy control subjects and 14 multiply affected bipolar families was investigated. With the case-control design the distribution of alleles between the two groups did not approach statistical significance. The extended transmission disequilibrium test (ETDT) performed in our families did not show evidence for linkage disequilibrium. Parametric and non-parametric linkage analysis also did not provide support for linkage between any of the four loci and BPAD. Our data do not support the hypothesis that variation at the polymorphic CAG/CTG repeat loci ERDA-1, SEF2-1b, MAB21L or KCNN3 influence susceptibility to BPAD in our sample.
Authors:
I V Meira-Lima; J Zhao; P Sham; A C Pereira; J E Krieger; H Vallada
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular psychiatry     Volume:  6     ISSN:  1359-4184     ISO Abbreviation:  Mol. Psychiatry     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-08-29     Completed Date:  2001-10-18     Revised Date:  2009-10-27    
Medline Journal Info:
Nlm Unique ID:  9607835     Medline TA:  Mol Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  565-9     Citation Subset:  IM    
Affiliation:
Laboratory of Neuroscience (LIM 27), Institute of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Alleles
Bipolar Disorder / genetics*
Case-Control Studies
DNA-Binding Proteins*
Female
Gene Frequency
Genetic Markers
Genotype
Helix-Loop-Helix Motifs
Homeodomain Proteins / genetics*
Humans
Linkage (Genetics)
Male
Middle Aged
Polymorphism, Genetic*
Potassium Channels / genetics*
Potassium Channels, Calcium-Activated*
Reference Values
Small-Conductance Calcium-Activated Potassium Channels
Statistics as Topic
Statistics, Nonparametric
TCF Transcription Factors
Trans-Activators / genetics*
Transcription Factors*
Trinucleotide Repeats*
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Genetic Markers; 0/Homeodomain Proteins; 0/Potassium Channels; 0/Potassium Channels, Calcium-Activated; 0/Small-Conductance Calcium-Activated Potassium Channels; 0/TCF Transcription Factors; 0/TCF4 protein, human; 0/Tcf7L2 transcription factor; 0/Trans-Activators; 0/Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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