Document Detail


Association of leukocyte count with progression of aortic atheroma in stroke/transient ischemic attack patients.
MedLine Citation:
PMID:  17901385     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Leukocyte count is an independent predictor of stroke. We investigated the association between leukocyte count and progression of aortic atheroma over 12 months in stroke/transient ischemic attack (TIA) patients. METHODS: Consecutive ischemic stroke and transient ischemic attack patients underwent 12-month sequential transesophageal echocardiography and were assessed for total and differential leukocyte counts on admission. Paired aortic plaque images were assessed for several parameters, including changes in grade, intimal-medial thickness (IMT), and cross-sectional area. Multivariate linear and logistic regressions were used to calculate the effect of leukocyte count on the change in aortic atheromas over 12 months. RESULTS: Of the 115 participants (mean+/-SD age, 64.6+/-11.9 years; 53.1% men; 73.4% white, 24.2% black, and 2.3% Asian), 45 (35%) showed clinically significant progression of aortic atheromas (maximal change in IMT >0.70 mm over 12 months). The mean admission leukocyte count was higher in the progression group compared with the no-progression group (8.6+/-2.2 vs 7.3+/-2.2 x 10(9)/L respectively, P=0.002). Each unit increase in leukocyte count was associated with a 0.26-mm increase in aortic arch IMT over 12 months (P=0.006). After adjustment for other atherosclerosis risk factors, the relation persisted (mean increase in aortic arch IMT per unit increase in leukocyte count=0.27 mm, P=0.007). Each unit increase in leukocyte count was associated with an increased risk of significant progression of aortic atheromas (adjusted odds ratio=1.33; 95% CI, 1.09 to 1.61). CONCLUSIONS: In stroke/transient ischemic attack patients, leukocyte count is independently associated with the progression of aortic atheroma over 12 months (>0.70 mm), which is associated with cardiovascular risk.
Authors:
Souvik Sen; Alan Hinderliter; Pranab K Sen; Jennifer Simmons; Vicky A LeGrys; James Beck; Steven Offenbacher; Kevin Moss; Stephen M Oppenheimer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-09-27
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  38     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-30     Completed Date:  2007-11-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2900-5     Citation Subset:  IM    
Affiliation:
Department of Neurology, University of North Carolina, Chapel Hill, NC, USA. SenS@neurology.unc.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Aorta, Thoracic / immunology,  pathology,  ultrasonography
Aortic Diseases / epidemiology*,  immunology*,  ultrasonography
Atherosclerosis / epidemiology*,  immunology*,  ultrasonography
Biological Markers / analysis
Cohort Studies
Comorbidity
Disease Progression
Female
Humans
Inflammation / diagnosis,  immunology*,  physiopathology
Ischemic Attack, Transient / epidemiology,  immunology,  ultrasonography
Leukocyte Count
Male
Middle Aged
Predictive Value of Tests
Risk Factors
Stroke / epidemiology*
Grant Support
ID/Acronym/Agency:
1K23NS02117/NS/NINDS NIH HHS; RR00046/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers

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