| Association of the leptin gene with knee osteoarthritis susceptibility in a Han Chinese population: a case-control study. | |
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MedLine Citation:
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PMID: 20664554 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Previous studies have suggested that leptin works as a key regulator in the pathogenesis of osteoarthritis (OA), and genetic factors modulate OA. This study assessed the contribution of leptin gene (LEP) polymorphism(s) to knee OA among Han Chinese. Three tag single-nucleotide polymorphisms (SNPs) covering all those LEP SNPs of which the minor allele frequencies were over 10% were selected. Study subjects (697 patients and 699 controls) were divided into four groups (underweight, normal weight, overweight and obese) by body mass index (BMI). Allele and genotype frequencies in the three tag SNPs were significantly different in the normal weight and overweight groups. In the normal weight, overweight and obese groups, BMI (P=4.3 × 10(-5), 0.012 and 0.009, respectively) and gender (P=3.5 × 10(-22), 5.1 × 10(-23) and 2.1 × 10(-8), respectively) were effective factors. Age was an independent effective factor in the overweight group (P=0.009). Haplotypes were associated with OA in the normal weight group (CAT, P=0.015) and the overweight group (AGC, P=0.015). Our results suggest an association between LEP and knee OA in the normal weight and overweight groups among Han Chinese. |
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Authors:
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Jianghui Qin; Dongquan Shi; Jin Dai; Lunqing Zhu; Aspasia Tsezou; Qing Jiang |
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Publication Detail:
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Type: Journal Article Date: 2010-07-22 |
Journal Detail:
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Title: Journal of human genetics Volume: 55 ISSN: 1435-232X ISO Abbreviation: J. Hum. Genet. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9808008 Medline TA: J Hum Genet Country: Japan |
Other Details:
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Languages: eng Pagination: 704-6 Citation Subset: IM |
Affiliation:
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The Center of Diagnosis and Treatment for Joint Disease, Department of Orthopaedic Surgery, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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