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Association of left ventricular mass with all-cause mortality, myocardial infarction and stroke.
MedLine Citation:
PMID:  23049815     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Our aim was to assess the association of left ventricular mass with mortality and nonfatal cardiovascular events.
METHODOLOGY/PRINCIPAL FINDINGS: Left ventricular mass was measured by echocardiography in 40138 adult patients (mean age 61.1 ± 16.4 years, 52.5% male). The primary endpoint was all-cause mortality. Secondary endpoints included nonfatal myocardial infarction and nonfatal stroke. During a mean follow-up period of 5.6 ± 3.9 years, 9181 patients died, 901 patients had a nonfatal myocardial infarction, and 2139 patients had a nonfatal stroke. Cumulative 10-year mortality was 26.8%, 31.9%, 37.4% and 46.4% in patients with normal, mildly, moderately and severely increased left ventricular mass, respectively (p<0.001). Ten-year rates of nonfatal myocardial infarction and stroke ranged from 3.2% and 6.7% in patients with normal left ventricular mass to 5.3% and 12.7% in those with severe increase in left ventricular mass, respectively. After multivariate adjustment, left ventricular mass remained an independent predictor of all-cause mortality (hazard ratio [HR] per 100 g increase 1.21, 95% confidence interval [CI] 1.14-1-27, p<0.001 in women, and HR 1.09, 95% CI 1.04-1-13, p<0.001 in men), myocardial infarction (HR 1.60, 95% CI 1.31-1.94, p<0.001 in women and HR 1.15, 95% CI 1.02-1.29, p=0.019 in men) and stroke (HR 1.26, 95% CI 1.13-1.40, p<0.001 in women and HR 1.19, 95% CI 1.09-1.30, p<0.001 in men).
CONCLUSIONS/SIGNIFICANCE: Left ventricular mass has a graded and independent association with all-cause mortality, myocardial infarction and stroke.
Alberto Bouzas-Mosquera; Francisco J Broullón; Nemesio Álvarez-García; Jesús Peteiro; Víctor X Mosquera; Alfonso Castro-Beiras
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Publication Detail:
Type:  Journal Article     Date:  2012-09-26
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-10     Completed Date:  2013-04-22     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e45570     Citation Subset:  IM    
Department of Cardiology, Hospital Universitario A Coruña, A Coruña, Spain.
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MeSH Terms
Heart Ventricles / pathology*,  ultrasonography
Hypertrophy, Left Ventricular / complications*,  mortality,  pathology,  ultrasonography
Middle Aged
Myocardial Infarction / complications*,  mortality,  pathology,  ultrasonography
Risk Factors
Severity of Illness Index
Sex Factors
Stroke / complications*,  mortality,  pathology,  ultrasonography
Survival Analysis

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