| Association of killer cell immunoglobulin-like receptor genotypes with vascular arterial events and anticardiolipin antibodies in patients with lupus. | |
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MedLine Citation:
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PMID: 18755860 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine whether killer cell immunologlobulin-like receptor (KIR) genotypes are associated with vasculitis, vascular arterial events or anticardiolipin (aCL) antibodies in patients with lupus. A total of 304 patients followed prospectively at the University of Toronto Lupus Clinic were assessed for the occurrence of vasculitis and vascular arterial events. Molecular HLA-C and KIR (presence or absence of KIR2DL1, 2DL2, 2DL3, 2DS1 and 2DS2) genotyping were performed. Chi-square and logistic regression were used to analyse association between KIR genes and vascular arterial events and aCL antibodies. In patients with vascular arterial events, there was a significant increase in KIR2DS2 (60% vs 45%, P = 0.02) and in KIR2DL2 (62% vs 47%, P = 0.01) compared with patients without events. There was no increase in activating KIR genotypes in patients with vasculitis. In patients with aCL antibodies, significant increases were seen in KIR2DS2 (54% vs 41%, P = 0.03) and KIR2DL2 (58% vs 41%, P = 0.003), but KIR2DL3 was decreased (87% vs 95%, P = 0.03). Logistic regression confirmed independent association of KIR2DS2 with vascular arterial events. We found an increase in KIR2DS2 in lupus patients with vascular arterial events, but not in patients with vasculitis. |
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Authors:
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Sma Toloza; Fj Pellett; V Chandran; D Ibanez; Mb Urowitz; Dd Gladman |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Lupus Volume: 17 ISSN: 0961-2033 ISO Abbreviation: Lupus Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-29 Completed Date: 2009-01-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204265 Medline TA: Lupus Country: England |
Other Details:
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Languages: eng Pagination: 793-8 Citation Subset: IM |
Affiliation:
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Division of Rheumatology, Centre for Prognosis studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Angina Pectoris / blood, epidemiology, genetics Antibodies, Anticardiolipin / blood Comorbidity European Continental Ancestry Group / genetics Female Genotype* HLA-C Antigens / blood Humans Ischemic Attack, Transient / blood, epidemiology, genetics Lupus Erythematosus, Systemic / blood*, epidemiology, genetics* Male Myocardial Infarction / blood, epidemiology, genetics Peripheral Vascular Diseases / blood, epidemiology, genetics Prospective Studies Receptors, KIR / genetics* Risk Factors Stroke / blood, epidemiology, genetics Vasculitis / blood, epidemiology, genetics Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Anticardiolipin; 0/HLA-C Antigens; 0/Receptors, KIR |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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