Document Detail


Association of an intronic variant of the heme oxygenase-1 gene with hypertension in northern Chinese Han population.
MedLine Citation:
PMID:  19886851     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Heme oxygenase was regarded as a regulator of oxidative stress, which was believed to underlie the etiology of hypertension. To assess the effect of its encoded genes (HMOX1 and HMOX2) on hypertension, we designed a case-control study in 503 cases and 490 controls. The results indicated that the rs9607267 of the HMOX1 gene was significantly associated with essential hypertension (EH) and the Hap3(T-C-G) of the HMOX1 gene was also significantly associated with the risk of EH. No association was observed between the HMOX2 gene and EH. The multifactor-dimensionality reduction analyses results did not show any interaction between the HMOX1 and HMOX2 genes underlying the development of hypertension.
Authors:
Li Yun; Liu Xiaoli; Zhao Qi; Wang Laiyuan; Lu Xiangfeng; Shen Chong; Huang Jianfeng; Chen Shufeng; Li Hongfan; Dongfeng Gu
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  31     ISSN:  1525-6006     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-11-05     Completed Date:  2010-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  534-43     Citation Subset:  IM    
Affiliation:
Department of Evidence-Based Medicine and Division of Population Genetics, Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, PR China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Asian Continental Ancestry Group / genetics*
Base Sequence
Case-Control Studies
China
DNA Primers / genetics
Female
Gene Frequency
Genetic Variation*
Haplotypes
Heme Oxygenase (Decyclizing) / genetics
Heme Oxygenase-1 / genetics*
Humans
Hypertension / enzymology*,  etiology,  genetics*
Introns
Male
Middle Aged
Polymorphism, Single Nucleotide
Chemical
Reg. No./Substance:
0/DNA Primers; EC 1.14.99.3/Heme Oxygenase (Decyclizing); EC 1.14.99.3/Heme Oxygenase-1; EC 1.14.99.3/heme oxygenase-2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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