| Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs. | |
| | |
MedLine Citation:
|
PMID: 17371467 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: A small number of immune response genes have been consistently associated with the common autoimmune conditions. Recently, a linkage disequilibrium (LD) mapping approach, using tag single nucleotide polymorphisms (SNPs), identified genetic association between type 1 diabetes (T1D) and the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region on chromosome 10p15. Because certain autoimmune diseases, such as autoimmune thyroid disease (AITD) and T1D cluster together in certain families, we sought to determine if the TID-associated CD25 region was also associated with Graves' disease (GD). DESIGN: We performed a case-control association study of 20 tag SNPs. PATIENTS: 1896 GD patients were collected from seven major centres in the UK and 1822 geographically matched controls from the 1958 British Birth Cohort. MEASUREMENTS: The 20 tag SNPs were analysed using a multilocus test to identify an association between GD and the CD25 region. Odds ratios (ORs) were calculated for the tag SNPs, allowing a comparison with previous results for T1D. RESULTS The multilocus test provided statistical evidence of an association between GD and the CD25 region (P = 4.5 x 10(-4)), with the pattern of association of the 20 tag SNPs similar to that found in T1D. CONCLUSIONS Association with GD, as well as that previously reported with T1D, suggests that the CD25 region is acting as a general susceptibility locus for autoimmune disease, and is consistent with a major role for the IL-2-receptor pathway in the development and function of T cells in the control of autoimmunity. |
| | |
Authors:
|
Oliver J Brand; Christopher E Lowe; Joanne M Heward; Jayne A Franklyn; Jason D Cooper; John A Todd; Stephen C L Gough |
Related Documents
:
|
20130027 - Visualizing snp statistics in the context of linkage disequilibrium using ld-plus. 20018057 - Detecting single-nucleotide polymorphism by single-nucleotide polymorphism interactions... 19083727 - Coding region mitochondrial dna snps: targeting east asian and native american haplogro... 21047277 - Polymorphisms of insulin-like growth factor-1 (igf-1) and igf-1 receptor (igf-1r) contr... 17666777 - Prevalence of complex vertebral malformation carriers among polish holstein-friesian bu... 18603297 - Detection of bcr-abl gene mutations in philadelphia chromosome positive leukemia patien... |
Publication Detail:
|
Type: Journal Article; Multicenter Study |
Journal Detail:
|
Title: Clinical endocrinology Volume: 66 ISSN: 0300-0664 ISO Abbreviation: Clin. Endocrinol. (Oxf) Publication Date: 2007 Apr |
Date Detail:
|
Created Date: 2007-03-20 Completed Date: 2007-09-18 Revised Date: 2007-10-30 |
Medline Journal Info:
|
Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: England |
Other Details:
|
Languages: eng Pagination: 508-12 Citation Subset: IM |
Affiliation:
|
Department of Medicine, Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Case-Control Studies Diabetes Mellitus, Type 1 / genetics Female Gene Frequency Genetic Markers Genetic Predisposition to Disease Genotype Graves Disease / genetics* Great Britain Health Surveys Humans Interleukin-2 Receptor alpha Subunit / genetics* Logistic Models Male Middle Aged Odds Ratio Polymorphism, Single Nucleotide* Sequence Tagged Sites |
| Chemical | |
Reg. No./Substance:
|
0/Genetic Markers; 0/Interleukin-2 Receptor alpha Subunit |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Macroprolactinomas and epilepsy.
Next Document: Metabolic characteristics of women with polycystic ovaries and oligo-amenorrhoea but normal androgen...