Document Detail


Association of interleukin 18 gene polymorphism with susceptibility to the development of acute lung injury after cardiopulmonary bypass surgery.
MedLine Citation:
PMID:  20522205     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The activation and recruitment of neutrophil cells in lung tissue are the characteristic features of acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). Interleukin 18 (IL-18) is a potent activator and inducer of accumulating neutrophils in lung, and higher IL-18 level has been shown to link to IL-18 gene -607C/C genotype. Therefore, the polymorphisms in IL-18 gene promoter were examined to investigate the association with susceptibility to the development of ALI after cardiopulmonary bypass (CPB) surgery in this study. The results showed the significant involvement of -607C/ genotype in patients with ALI (n = 18, 18/43, 41.9%) compared with those patients without ALI (n = 32, 32/155, 20.6%, P = 0.0037) and healthy controls (n = 198, 53/198, 26.8%, P = 0.06). The frequencies of -607C/C,C/A,A/A genotypes were 41.9%, 46.5%, and 11.6% in patients with ALI and 20.6%, 47.1%, and 32.3% in patients without ALI. The allelic frequency of C (65.1%) was significantly higher in patients with ALI than that of patients without ALI (44.2%) [odds ratio(OR) = 0.42, 95% confidence interval (CI) = 0.26 - 0.70; P = 0.0006]. No significant association of -137 polymorphism with susceptibility of ALI was found. There were no significant differences between the patients who had undergone CPB operation and healthy controls. In conclusion, our findings suggest that -607C/C genotype in IL-18 gene plays a pivotal role in the development of ALI after CPB surgery in Chinese Han population.
Authors:
S Chen; L Xu; J Tang
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Tissue antigens     Volume:  76     ISSN:  1399-0039     ISO Abbreviation:  Tissue Antigens     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-10     Completed Date:  2010-12-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0331072     Medline TA:  Tissue Antigens     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  245-9     Citation Subset:  IM    
Affiliation:
Department of Thoracic Surgery, Jiangsu Province Tumor Hospital, Nanjing Medical University, Nanjing, PR China.
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MeSH Terms
Descriptor/Qualifier:
Acute Lung Injury / genetics*,  pathology
Cardiopulmonary Bypass*
Case-Control Studies
DNA / analysis,  genetics
Female
Gene Frequency
Genetic Predisposition to Disease*
Genotype
Heart Diseases / genetics,  surgery*
Humans
Interleukin-18 / genetics*
Male
Middle Aged
Polymerase Chain Reaction
Polymorphism, Genetic / genetics*
Promoter Regions, Genetic / genetics
Chemical
Reg. No./Substance:
0/Interleukin-18; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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