| Association of interleukin 18 gene polymorphism with susceptibility to the development of acute lung injury after cardiopulmonary bypass surgery. | |
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MedLine Citation:
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PMID: 20522205 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The activation and recruitment of neutrophil cells in lung tissue are the characteristic features of acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). Interleukin 18 (IL-18) is a potent activator and inducer of accumulating neutrophils in lung, and higher IL-18 level has been shown to link to IL-18 gene -607C/C genotype. Therefore, the polymorphisms in IL-18 gene promoter were examined to investigate the association with susceptibility to the development of ALI after cardiopulmonary bypass (CPB) surgery in this study. The results showed the significant involvement of -607C/ genotype in patients with ALI (n = 18, 18/43, 41.9%) compared with those patients without ALI (n = 32, 32/155, 20.6%, P = 0.0037) and healthy controls (n = 198, 53/198, 26.8%, P = 0.06). The frequencies of -607C/C,C/A,A/A genotypes were 41.9%, 46.5%, and 11.6% in patients with ALI and 20.6%, 47.1%, and 32.3% in patients without ALI. The allelic frequency of C (65.1%) was significantly higher in patients with ALI than that of patients without ALI (44.2%) [odds ratio(OR) = 0.42, 95% confidence interval (CI) = 0.26 - 0.70; P = 0.0006]. No significant association of -137 polymorphism with susceptibility of ALI was found. There were no significant differences between the patients who had undergone CPB operation and healthy controls. In conclusion, our findings suggest that -607C/C genotype in IL-18 gene plays a pivotal role in the development of ALI after CPB surgery in Chinese Han population. |
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Authors:
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S Chen; L Xu; J Tang |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Tissue antigens Volume: 76 ISSN: 1399-0039 ISO Abbreviation: Tissue Antigens Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-10 Completed Date: 2010-12-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0331072 Medline TA: Tissue Antigens Country: Denmark |
Other Details:
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Languages: eng Pagination: 245-9 Citation Subset: IM |
Affiliation:
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Department of Thoracic Surgery, Jiangsu Province Tumor Hospital, Nanjing Medical University, Nanjing, PR China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Lung Injury
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genetics*,
pathology Cardiopulmonary Bypass* Case-Control Studies DNA / analysis, genetics Female Gene Frequency Genetic Predisposition to Disease* Genotype Heart Diseases / genetics, surgery* Humans Interleukin-18 / genetics* Male Middle Aged Polymerase Chain Reaction Polymorphism, Genetic / genetics* Promoter Regions, Genetic / genetics |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-18; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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