Document Detail


Association of interleukin-15 protein and interleukin-15 receptor genetic variation with resistance exercise training responses.
MedLine Citation:
PMID:  15531573     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interleukin-15 (IL-15) is an anabolic cytokine that is produced in skeletal muscle and directly affects muscle anabolism in animal and in vitro models. The contribution of IL-15 variability in muscle responses to 10 wk of resistance exercise training in young men and women was examined by measuring acute and chronic changes in IL-15 protein in plasma and characterizing genetic variation in the IL-15 receptor-alpha gene (IL15RA). Participants trained 3 days a week at 75% of one repetition maximum, performing three sets (6-10 repetitions) of 13 resistance exercises. Plasma IL-15 protein was significantly increased (P < 0.05) immediately after acute resistance exercise but did not change with training and was not associated with variability in muscle responses with training. A single nucleotide polymorphism in exon 7 of IL15RA was strongly associated with muscle hypertrophy and accounted for 7.1% of the variation in regression modeling. A polymorphism in exon 4 was also independently associated with muscle hypertrophy and accounted for an additional 3.5% of the variation in hypertrophy. These results suggest that IL-15 is an important mediator of muscle mass response to resistance exercise training in humans and that genetic variation in IL15RA accounts for a significant proportion of the variability in this response.
Authors:
Steven E Riechman; G Balasekaran; Stephen M Roth; Robert E Ferrell
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  97     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-08     Completed Date:  2005-04-06     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2214-9     Citation Subset:  IM    
Affiliation:
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA 15260, USA. riechman@helix.hgen.pitt.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Exercise / physiology*
Female
Genetic Variation*
Haplotypes
Humans
Interleukin-15 / blood*
Male
Muscle, Skeletal / anatomy & histology,  physiology*
Phenotype
Receptors, Interleukin-15
Receptors, Interleukin-2 / genetics*,  metabolism
Regression Analysis
Signal Transduction / physiology
Grant Support
ID/Acronym/Agency:
5 P20 AR44811-04/AR/NIAMS NIH HHS; AG-022791/AG/NIA NIH HHS; AG-05893/AG/NIA NIH HHS; DK-45204/DK/NIDDK NIH HHS; P30-DK046204/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/IL15RA protein, human; 0/Interleukin-15; 0/Receptors, Interleukin-15; 0/Receptors, Interleukin-2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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