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Association of interleukin-13 SNP rs1800925 with allergic rhinitis risk: A meta-analysis based on 1,411 cases and 3,169 controls.
MedLine Citation:
PMID:  22750299     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Studies investigating the association between interleukin-13 (IL-13) single nucleotide polymorphism (SNP) rs1800925 and allergic rhinitis risk have reported conflicting results. The aim of the present study was to conduct a meta-analysis assessing the possible association of IL-13 SNP rs1800925 with allergic rhinitis risk. The relevant studies were identified through a search of PubMed, Embase, ISI Web of Knowledge and Chinese National Knowledge Infrastructure until December 2011 and selected on the basis of the established inclusion criteria for publications. Five studies were included in the present meta-analysis (1,411 cases and 3,169 controls). The combined results based on all studies showed that IL-13 SNP rs1800925 was not associated with increased allergic rhinitis risk (T versus C: odds ratio (OR)=1.06, 95% confidence interval (CI)=0.94~1.20; C/T versus C/C: OR=1.12, 95% CI=0.97~1.29; T/T versus C/C: OR=1.00, 95% CI=0.69~1.44; C/T+T/T versus CC: OR=1.10, 95% CI=0.96~1.27; T/T versus C/C+C/T: OR=0.91, 95% CI=0.64~1.31). This meta-analysis supported that IL-13 SNP rs1800925 was not associated with allergic rhinitis.
Authors:
Xinjiang Ying; Ruxin Zhang; Shudong Yu; Jing Wu; Hong Wang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-28
Journal Detail:
Title:  Gene     Volume:  -     ISSN:  1879-0038     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-7-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7706761     Medline TA:  Gene     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
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