| Association of inhaled corticosteroid use with cataract extraction in elderly patients. | |
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MedLine Citation:
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PMID: 9707144 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: The use of systemic corticosteroids is a known risk factor for the development of cataracts. OBJECTIVE: To determine whether treatment with inhaled corticosteroids is associated with cataract extraction in the elderly. DESIGN: Case-control study. SETTING: Quebec universal health insurance program for all elderly (provincial health insurance plan database [RAMQ database]). PATIENTS: RAMQ enrollees 70 years and older. The 3677 cases were patients with a cataract extraction between 1992 and 1994. The 21868 controls were randomly selected from patients who did not have a diagnosis of cataract and matched to cases on the index date of the case. MAIN OUTCOME MEASURES: Odds ratio of cataract extraction in patients with prolonged cumulative exposure to inhaled corticosteroids compared with nonusers. RESULTS: Excluding patients with systemic steroid treatment and after adjusting for age, sex, diabetes, systemic hypertension, glaucoma, ophthalmic steroids, and the number of physician claims for services, use of inhaled corticosteroids for more than 3 years was associated with undergoing cataract extraction (odds ratio [OR], 3.06; 95% confidence interval [CI], 1.53-6.13). For high average daily doses of beclomethasone or budesonide (>1 mg), the OR was elevated after more than 2 years of treatment (OR, 3.40; 95% CI, 1.49-7.76), whereas for low to medium doses (< or =1 mg) of these drugs, the OR was 1.63 (95% CI, 0.85-3.13) after 2 years. CONCLUSION: Prolonged administration of high doses of inhaled corticosteroids increases the likelihood of undergoing cataract extraction in elderly patients. Further studies are needed to investigate the risk of developing cataracts for low to medium doses over longer periods. |
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Authors:
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E Garbe; S Suissa; J LeLorier |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: JAMA : the journal of the American Medical Association Volume: 280 ISSN: 0098-7484 ISO Abbreviation: JAMA Publication Date: 1998 Aug |
Date Detail:
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Created Date: 1998-08-25 Completed Date: 1998-08-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7501160 Medline TA: JAMA Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 539-43 Citation Subset: AIM; IM |
Affiliation:
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Potsdam Institute of Pharmacoepidemiology and Technology Assessment, Germany. 106700.3205@compuserve.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Aged Aged, 80 and over Anti-Inflammatory Agents / adverse effects Case-Control Studies Cataract Extraction / statistics & numerical data* Female Glucocorticoids / administration & dosage, adverse effects* Humans Male Odds Ratio Steroids |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Glucocorticoids; 0/Steroids |
| Comments/Corrections | |
Comment In:
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JAMA. 1999 Mar 3;281(9):791-2; author reply 792-3
[PMID:
10070990
]
JAMA. 1999 Mar 3;281(9):792-3 [PMID: 10070991 ] JAMA. 1999 Mar 3;281(9):791; author reply 792-3 [PMID: 10070988 ] JAMA. 1999 Mar 3;281(9):791; author reply 792-3 [PMID: 10070987 ] JAMA. 1999 Mar 3;281(9):791; author reply 792-3 [PMID: 10070989 ] |
Erratum In:
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JAMA 1998 Dec 2;280(21):1830 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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