|Association of inflammation with atrial fibrillation in hyperthyroidism.|
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|PMID: 23341838 Owner: NLM Status: PubMed-not-MEDLINE|
|OBJECTIVES: The aim of this study was to evaluate the relationship between inflammation and development of atrial fibrillation (AF) in patients with hyperthyroidism.
METHODS: A total of 65 patients with newly diagnosed hyperthyroidism, 35 of whom were in sinus rhythm and 30 of whom in AF. Thirty five age- and gender-matched patients in a control group were included in the study. Factors associated with the development of AF were evaluated by multivariate regression analysis.
RESULTS: FACTORS ASSOCIATED WITH AF IN MULTIVARIATE ANALYSIS INCLUDED HIGH SENSITIVITY C REACTIVE PROTEIN (HSCRP) [ODDS RATIO (OR): 11.19; 95% confidence interval (95% CI): 1.80-69.53; P = 0.003], free T4 (OR: 8.76; 95% CI: 2.09-36.7; P = 0.003), and left atrial diameter (OR: 1.25; 95% CI: 1.06-1.47; P = 0.008).
CONCLUSIONS: The results of the present study suggest that HsCRP, an indicator of inflammation, free T4 and left atrial diameter are associated with the development AF in patients with hyperthyroidism.
|Mehmet Ozaydin; Ali Kutlucan; Yasin Turker; Banu Koroglu; Akif Arslan; Bayram A Uysal; Dogan Erdogan; Ercan Varol; Abdullah Dogan|
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|Type: Journal Article|
|Title: Journal of geriatric cardiology : JGC Volume: 9 ISSN: 1671-5411 ISO Abbreviation: J Geriatr Cardiol Publication Date: 2012 Dec|
|Created Date: 2013-01-23 Completed Date: 2013-01-24 Revised Date: 2013-04-18|
Medline Journal Info:
|Nlm Unique ID: 101237881 Medline TA: J Geriatr Cardiol Country: China|
|Languages: eng Pagination: 344-8 Citation Subset: -|
|Department of Cardiology, Suleyman Demirel University, Kurtulus Mah 122. cad. Hatice Halici apt. no: 126, 32040 Isparta, Turkey.|
|APA/MLA Format Download EndNote Download BibTex|
Journal ID (nlm-ta): J Geriatr Cardiol
Journal ID (iso-abbrev): J Geriatr Cardiol
Journal ID (publisher-id): JGC
Publisher: Science Press
Institute of Geriatric Cardiology
Received Day: 25 Month: 6 Year: 2012
Revision Received Day: 16 Month: 8 Year: 2012
Accepted Day: 19 Month: 10 Year: 2012
Print publication date: Month: 12 Year: 2012
Volume: 9 Issue: 4
First Page: 344 Last Page: 348
PubMed Id: 23341838
Publisher Id: jgc-09-04-344
|Association of inflammation with atrial fibrillation in hyperthyroidism|
|Bayram A. Uysal1|
1Department of Cardiology, Suleyman Demirel University, Kurtulus Mah 122. cad. Hatice Halici apt. no: 126, 32040 Isparta, Turkey
2Department of Internal Medicine, Gulkent Hospital, Atatürk Blv, 10432, 32200 Sanayi Isparta, Turkey
3Department of Cardiology, Gulkent Hospital, Atatürk Blv, 10432, 32200 Sanayi, Isparta, Turkey
|Correspondence: Correspondence to: Mehmet Ozaydin, MD, Professor, Department of Cardiology, Suleyman Demirel University, Kurtulus Mah, 122. cad. Hatice Halici apt. no: 126, 32040, Isparta, Turkey. E-mail: firstname.lastname@example.orgTelephone:+90-532-413-9528Fax:+90-246-232-6280
Atrial fibrillation (AF) is the most common cardiac complication of hyperthyroidism, occurring in up to 15% of patients. Hyperthyroidism is defined as a hyper production of triiodothyronine (T3) hormone and an increase in peripheral thyroxine (T4)., AF in hyperthyroidism is associated with increased thrombo-embolic risk and mortality and inflammation has been shown to be associated with AF in different patient populations.–
The relationship between hyperthyroidism and inflammation is unclear. However, a case study reported that hyperthyroidism was associated with an interstitial inflammation of the atrioventricular node, the His-bundle and its branches at autopsy findings. The authors assumed that death was caused by an arrhythmia due to thyrotoxicosis. Pearce, et al. showed that C-reactive protein (CRP) levels were similar among euthyroid, non-goitrous controls and patients with toxic or no-ntoxic, multi-nodular, goiter, or Graves' disease. It has been reported that serum CRP levels did not correlate with thyroid hormone levels in hypothyroid subjects. However, when compared with euthyroid control subjects, patients with hyperthyroidism had significantly elevated serum levels of interleukin-8 and tumor necrosis factor alpha (TNF-α). Additionally, the mean serum levels of interleukin-6 (IL-6) and IL-8 were significantly elevated in both Graves' disease and toxic, nodular goiter patients compared with the controls. The elevations in serum levels of IL-1, IL-6 and IL-8 that occur in hyperthyroidism seem to result from the chronic effects of excess thyroid hormone rather than the accompanying autoimmune inflammatory condition produced by Graves' thyroid or eye disease. However, to the best of our knowledge, no previous studies have evaluated whether there is also a relationship between inflammation and the development of AF in patients with hyperthyroidism. Therefore, the aim of this study was to evaluate the relationship between serum levels of high-sensitivity C-reactive protein (HsCRP), as a marker of inflammation and the development of AF in patients with hyperthyroidism.
A total of 164 consecutive patients with newly diagnosed hyperthyroidism were screened between May 2008 and October 2008. Patients with hyperthyroidism and a history of electrocardiographically documented AF were assigned to the AF group (HT-AF) and, if no history of AF was evident, patients were placed in the sinus rhythm group (HT-SR). Exclusion criteria included: documented coronary artery disease, use of anti-arrhythmic drugs, prior valvular surgery, sepsis, electrolyte imbalance, inflammatory or autoimmune diseases, moderate to severe valvular disease, chronic obstructive pulmonary disease, history of renal or liver disease, pulmonary artery hypertension secondary to non-valvular causes, malignancy, left ventricular systolic dysfunction, hipophysis disease, use of anti-thyroid agents, and subclinical hyperthy-roidism. After screening, a total of 99 patients were excluded due to Graves' disease (n = 58), thyroiditis (n = 14), and subclinical hyperthyroidism (n = 27). Therefore, the remaining 65 patients with hyperthyroidism, 35 of whom in sinus rhythm (HT-SR group; toxic nodular goiter, n = 21; toxic multi-nodular goiter, n = 14) and 30 of whom in AF (HT-AF group: toxic nodular goiter, n = 19; toxic multi-nodular goiter, n = 11) constituted the study population. Thirty-five age- and gender-matched patients without hyperthyroidism or AF constituted the control group.
The M-mode, two-dimensional, and Doppler echocardiographic examinations were obtained using the GE VingMed System FiVe (Norway). Left ventricle (LV) mass was calculated using the following equation: LV mass = 0.8 × [1.04 × (LVEDD + LVPWT + IVST)3 – (LVEDD)3]; where LVEDD indicates the left ventricular end-diastolic diameter; LVPWT, the left ventricularposterior wall thickness; and IVST, the interventricular septum thickness.
Patients with hyperthyroidism underwent thyroid ultra-sonography (Shimadzu, SDU-2200 X Plus, Japan). Thyroid scintigraphy was performed and thyroid antibodies were measured in those exhibiting a thyroid nodule on thyroid ultrasound. Patients with autoimmune diseases causing hyperthyroidism were excluded from the study.
Blood samples were drawn from the antecubital vein and collected into tubes containing potassium EDTA. HsCRP levels were measured by Beckman-Coulter-Image kit (Beckman-Coulter-Image) using the nefelometric method. Thyroid function tests were measured by the chemilumines- cence immunoassay method (DPC-Immulite 2000).
Continuous variables were expressed as mean ± SD and categorical variables were presented as percentages. Continuous variables were compared using one-way ANOVA or Student-t test, and categorical variables were compared with chi-square test. Predictors of AF were determined by multivariate regression analysis. The association between variables and the occurrence of AF was represented by odds ratio (OR) and their accompanying 95% confidence interval (95% CI). Clinical echocardiographic and laboratory findings in Table 1 were evaluated and those factors with P < 0.10 in Table 1 have been accepted as potential predictors. Therefore, T3, T4, thyroid stimulating hormone (TSH), left atrial diameter, LV mass, and serum HsCRP levels have been entered into a multivariate logistic regression analysis. P < 0.05 was considered significant.
A total of 65 patients with hyperthyroidism, 35 of whom in HT-SR group and 30 of whom in HT-AF group and 35 patients in the control group were studied. Patients' characteristics are presented in Table 1. Clinical findings were similar among the three groups (All P values > 0.05, Table 1).
Left atrial diameter was larger in the HT-AF group than the HT-SR group (P < 0.0001) and the control group (P < 0.0001). However, HT-SR and control groups had similar left atrial dia- meters (P = 0.19). LV mass was higher in the HT-AF group than the HT-SR group (P = 0.027) and the control group (P = 0.003). However, HT-SR group and control group had similar LV mass (P = 0.719).
HsCRP levels were higher in the HT-AF group compared to the HT-SR group (P = 0.02) and the control group (P = 0.001). However, similar values were found between the HT- SR and the control groups (P = 0.63).
Free T3 levels were higher in the HT-AF group compared to the HT-SR group (P = 0.04) and the control group (P < 0.0001) although the levels were higher in the HT-SR group as compared to the control group (P = 0.02).
Free T4 levels were higher in the HT-AF group compared to the HT-SR group (P < 0.0001) and the control group (P < 0.0001) and they were higher in the HT-SR group as compared to the control group (P = 0.02).
TSH levels were higher in the control group compared to the HT-AF group (P < 0.0001) and the HT-SR group (P < 0.0001). However, similar values were found between the HT-AF group and the HT-SR group (P = 1).
Medication use was similar among the groups (Table 1). Factors associated with AF in multivariate analysis found in Table 2 included, HsCRP (OR: 11.19; 95% CI: 1.80–69.53; P = 0.003), free T4 (OR: 8.76; 95% CI: 2.09–36.7; P = 0.003) and left atrial diameter (OR: 1.25; 95% CI: 1.06– 1.47; P = 0.008).
The present study suggests that HsCRP, an indicator of inflammation, free T4 and left atrial diameter are associated with the development AF in patients with hyperthyroidism.
Inflammation has been shown to be associated with AF in different patient populations.– According to our results, it appears the same association is also present in patients with hyperthyroidism.
Serum freeT4 levels have been found to be an independent predictor of AF., The present study is in agreement with previous reports and indicates that free T4 is independently associated with the development of AF in patients with hyperthyroidism.
Iwasaki, et al. found that patients with toxic nodular goiter had an increased incidence of AF compared to patients with Grave's disease, probably due to their increased age. Subclinical hyperthyroidism is a risk factor for the development of AF. However, we excluded the patients with subclinical hyperthyroidism and patients with Graves' disease. Therefore, if those patients were included in the present study, our results may have been different.
Iwasaki, et al. have shown that the majority of patients with hyperthyroidism and AF have an enlarged left atrium. Our study also supports those findings.
Generally, the initiation of AF occurs with premature complexes originating from the pulmonary veins, and the persistence of AF requires re-entry., Premature complexes occur secondary to automaticity or triggered activity., Increased automaticity and triggered activity in response to elevated T4 levels have been shown in isolated rabbit atrial and pulmonary vein cells., Wustmann, et al. have found increased supraventricular ectopic activity in normal hearts and those of patients with hyperthyroidism. Premature complexes may be secondary to a direct effect of thyroid hormones or their sympathomimetic effects. Re-entry mostly occurs in patients with structural,, or electrical remodeling. It was found that the incidence of abnormal right atrial electrograms was significantly higher in patients with lone paroxysmal AF than in patients without AF or hyperthyroidism. The atrial effective refractory period was significantly shorter in paroxysmal AF and hyperthyroidism than in patients without AF or hyperthyroidism, and patients with lone paroxysmal AF. A substrate in the atrium might not be essential to the genesis of AF in hyperthyroidism. By shortening the atrial refractory period and atrial action potential duration, thyroid hormones favor re-entry and the persistence of AF., The duration of the repolarization was shortened in rabbits given L-thyroxine and was prolonged in thyroidectomized rabbits. Elevation of left atrial pressure secondary to increased left ventricular mass and impaired ventricular relaxation and ischemia resulting from raised resting heart rate and inflammation, may also play a role in the occurrence of AF in these patients.
However, this was an observational study, and as such, we may will have missed some paroxysmal AF recurrences in the HT-SR group or control group. The data on left atrial area and volume are lacking. Drug treatment was not standardized. We did not include the patients with subclinical hyperthyroidism or Graves' disease that could have an affect on the results.
In conclusion, the present study suggests that high sensitivity C reactive protein, an indicator of inflammation, free T4 and left atrial diameter are associated with the development of AF in patients with hyperthyroidism.
|1.||Bielecka-Dabrowa A,Mikhailidis DP,Rysz J,et al. The mechanisms of atrial fibrillation in hyperthyroidismThyroid ResearchYear: 20092419341475|
|2.||Staffurt JS,Gibberd JS,Tang FS. Arterial embolism in thyrotoxicosis with atrial fibrillationBr Med JYear: 19772688690902055|
|3.||Selcuk MT,Selcuk H,Maden O,et al. Relationship between inflammation and atrial fibrillation in patients with isolated rheumatic mitral stenosisJ Heart Valve DisYear: 20071646847417944117|
|4.||Kumagai K,Nakashima H,Saku K. The HMG-CoA reductase inhibitor atorvastatin prevents atrial fibrillation by inhibiting inflammation in a canine sterile pericarditis modelCardiovasc ResYear: 20046210511115023557|
|5.||Chung MK,Martin DO,Sprecher D,et al. C-reactive protein elevation in patients with atrial arrhythmias: inflammatory mechanisms and persistence of atrial fibrillationCirculationYear: 20011042886289111739301|
|6.||Frustaci A,Chimenti C,Bellocci F,et al. Histological substrate of atrial biopsies in patients with lone atrial fibrillationCirculationYear: 199796118011849286947|
|7.||Ucer E,Gungor B,Erdinler IC,et al. High sensitivity CRP levels predict atrial tachyarrhythmias in rheumatic mitral stenosisAnn Noninvasive ElectrocardiolYear: 200813313818234004|
|8.||Chiu-Braga YY,Hayashi SY,Schafranski M,et al. Further evidence of inflammation in chronic rheumatic valve disease (CRVD): High levels of advanced oxidation protein products (AOPP) and high sensitive C-reactive proteinInt J CardiolYear: 200610927527615946754|
|9.||Golbasi Z,Ucar O,Keles T,et al. Increased levels of high sensitive C-reactive protein in patients with chronic rheumatic valve disease evidence of ongoing inflammationEur J Heart FailYear: 2002459359512413502|
|10.||Yetkin E,Erbay AR,Ileri M,et al. Levels of circulating adhesion molecules in rheumatic mitral stenosisAm J CardiolYear: 2001881209121111703977|
|11.||Ozaydin M,Turker Y,Erdogan D,et al. The association between previous statin use and development of atrial fibrillation in patients presenting with acute coronary syndromeInt J CardiolYear: 201014114715019106009|
|12.||Ortmann C,Pfeiffer H,Du Chesne A,et al. Inflammation of the cardiac conduction system in a case of hyperthyroidismInt J Legal MedYear: 199911227127410433039|
|13.||Pearce EN,Bogazzi F,Martino E,et al. The prevalence of elevated serum C-reactive protein levels in inflammatory and noninflammatory thyroid diseaseThyroidYear: 20031364364812964969|
|14.||Christ-Crain M,Meier C,Guglielmetti M,et al. Elevated C-reactive protein and homocysteine values: Cardiovascular risk factors in hypothyroidism? A cross-sectional and a double- blind, placebo-controlled trialAtherosclerosisYear: 200316637938612535752|
|15.||Senturk T,Kozaci LD,Kok F,et al. Proinflammatory cytokine levels in hyperthyroidismClin Invest MedYear: 200326586312722837|
|16.||Siddiqi A,Monson JP,Wood DF,et al. Serum cytokines in thyrotoxicosisJ Clin Endocrinol MetabYear: 19998443543910022397|
|17.||Devereux RB,Alonso DR,Lutas EM,et al. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findingsAm J CardiolYear: 1986574504582936235|
|18.||Gammage MD,Parle JV,Holder RL,et al. Association between serum free thyroxine concentration and atrial fibrillationArch Intern MedYear: 200716792893417502534|
|19.||Heeringa J,Hoogendoorn EH,van der Deure WM,et al. High-normal thyroid function and risk of atrial fibrillation: The rotterdam studyArch Intern MedYear: 20081682219222419001198|
|20.||Iwasaki T,Naka M,Hiramatsu K,et al. Echocardiographic studies on the relationship between atrial fibrillation and atrial enlargement in patients with hyperthyroidism of Graves' diseaseCardiologyYear: 19897610172523238|
|21.||Sawin CT,Geller A,Wolf PA,et al. Low serum thyrotropin concentrations as a risk factor for atrial fibrillation in older personsN Engl J MedYear: 1994331124912527935681|
|22.||Wang J,Liu L,Feng J,et al. Regional and functional factors determining induction and maintenance of atrial fibrillation in dogsAm J PhysiolYear: 1996271H148H1588760170|
|23.||Olsson SB. Atrial fibrillation-where do we stand today?J Intern MedYear: 2001250192811454138|
|24.||Chen YC,Chen SA,Chen YJ,et al. Effects of thyroid hormone on the arrhythmogenic activity of pulmonary vein cardiomyocytesJ Am Coll CardiolYear: 20023936637211788233|
|25.||Sun ZQ,Ojamaa K,Nakamura TY,et al. Thyroid hormone increases pacemaker activity in rat neonatal atrial myocytesJ Mol Cell CardiolYear: 20013381182411273733|
|26.||Wustmann K,Kucera JP,Zanchi A,et al. Activation of Electrical Triggers of Atrial Fibrillation in HyperthyroidismJ Clin Endocrinol MetabYear: 2008932104210818349059|
|27.||Biondi B,Fazio S,Coltorti F,et al. Clinical case seminar: Reentrant atrioventricular nodal tachycardia induced by levothyroxineJ Clin Endocrinol MetabYear: 199883264326459709925|
|28.||Tribulova N,Varon D,Polak-Charon S,et al. Aged heart as a model for prolonged atrial fibrilloflutterExp Clin CardiolYear: 199946472|
|29.||Kostin S,Klein G,Szalay Z,et al. Structural correlate of atrial fibrillation in human patientsCardiovasc ResYear: 20025436137912062341|
|30.||Spach MS,Heidlage JF. The stochastic nature of cardiac propagation at a microscopic level. An electrical description of myocardial architecture and its application to conductionCirc ResYear: 1995763663807859383|
|31.||Komiya N,Isomoto S,Nakao K,et al. Electrophysiological abnormalities of the atrial muscle in patients with paroxysmal atrial fibrillation associated with hyperthyroidismClin EndocrinolYear: 2002563944|
|32.||Freedberg AS,Papp JG,Vaughan-Williams EM. The effect of altered thyroid state on atrial intracellular potentialsJ PhysiolYear: 19702073573695499024|
|33.||Fazio S,Palmieri EA,Lombardi G,et al. Effects of Thyroid Hormone on the Cardiovascular SystemRecent Progr Horm ResYear: 200459315014749496|
|34.||Sgarbi JA,Villaca FG,Garbeline B,et al. The effects of early antithyroid therapy for endogenous subclinical hyperthyroidism in clinical and heart abnormalitiesJ Clin Endocrinol MetabYear: 2003881672167712679455|
|HT- SR Group (n = 35)||HT-AF Group (n = 30)||Control Group (n = 35)||P Value|
|Age, yr(s)||55 ± 11||57 ± 9||56 ± 13||0.74|
|Male||10 (28.6)||15 (50)||13 (37.1)||0.2|
|Diabetes mellitus||6 (17.1)||2 (6.7)||3 (8.6)||0.3|
|Hypertension||12 (34.3)||14 (46.7)||11 (31.4)||0.4|
|Smoking||6 (17.1)||11 (36.7)||7 (20)||0.14|
|ACEI or ARB||10 (28.6)||8 (28.6)||7 (20)||0.68|
|β-blocker||1 (2.9)||1 (3.3)||-||0.57|
|Diuretics||5 (14.3)||1 (3.3)||-||0.1|
|Calcium channel blocker||4 (11.4)||8 (26.7)||5 (14.3)||0.23|
|Statin||5(14.3)||2 (6.7)||3 (8.6)||0.56|
|Left atrial diameter (mm)||37 ± 5.3||42 ± 3||35.3 ± 2.3||< 0.001a|
|Left ventricular mass (g)||179.2 ± 27.9||200.1 ± 35.6||183.5 ± 32.3||0.038b|
|Left ventricular diastolic|
|dysfunction||3 (8.6)||4 (13.3)||4 (11.4)||0.8|
|Hs-CRP (mg/L)||0.36 ± 0.36||0.64 ± 0.56||0.27 ± 0.22||< 0.0013c|
|Free T3 (pg/mL)||4.6 ± 1.75||6.0 ± 3.45||3.08 ± 0.51||< 0.001d|
|Free T4 (ng/dL)||1.88 ± 0.7||3.0 ± 1.62||1.18 ± 0.23||< 0.001e|
|Free TSH (µIU/mL)||0.03 ±0.05||0.04 ± 0.05||1.9 ± 1.9||< 0.001f|
nt101Values are mean ± SD (range) or n (%).aMann-Whitney-U test: HT-SR vs. HT-AF, P < 0.001; HT-SR vs. control, P = 0.19; HT-AF vs. control, P < 0.0001. bScheffe correction: HT-SR vs. HT-AF, P = 0.027; HT-SR vs. control, P = 0.719; HT-AF vs. control, P = 0.003. cScheffe correction: HT-SR vs. HT-AF, P = 0.02; HT-SR vs. control, P = 0. 63; HT-AF vs. control, P = 0.001. dScheffe correction: Mann-Whitney-U test: HT-SR vs. HT-AF, P = 0.04; HT-SR vs. control, P = 0.02; HT-AF vs. control, P < 0.0001. eScheffe correction: HT-SR vs. HT-AF, P < 0.0001; HT-SR vs. control, P = 0.02; HT-AF vs. control, P < 0.0001. fScheffe correction: HT-SR vs. HT-AF, P = 1; HT-SR vs. control, P < 0.0001; HT-AF vs. control, P < 0.0001. ACEI: angiotensin converting-enzyme inhibitor; ARB: Angiotensin receptor blocker; HT-AF: hyperthyroidism-atrial fibrillation; HT-SR: hyperthyroidism-sinus rhythm; HsCRP: high sensitivity C-reactive protein; TNG: toxic nodular goiter; TMNG: toxic multi-nodular goiter.
Keywords: Atrial fibrillation, Hyperthyroidism, Inflammation.
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