Document Detail


Association of immune cell function assay with protocol biopsy findings and viral infections in well matched kidney transplant recipients.
MedLine Citation:
PMID:  20630132     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Cylex Immune Cell Function Assay (ICFA) is in clinical use, but little is known about its association with screening of viral infections or findings in protocol biopsies. PATIENTS AND METHODS: We analyzed ICFA in our well-matched kidney transplant population. Helsinki University Hospital patients who received a kidney transplant after July 2007 were analyzed. Patients with at least 6 months follow-up and ICFA measured together with the screening for cytomegalovirus (CMV), or polyomaviruses from urine or plasma, or patients with a protocol biopsy at 6 or 12 months taken at the time of the ICFA were included (n = 27). Immunosuppression was usually implemented with mycophenolate mofetil (MMF), steroids and cyclosporine A (CyA). Biopsies were analyzed with chronic allograft damage index (CADI). RESULTS: Mean immune response in 61 samples was 368 +/- 179 ATP ng/ml. Immune response was lower during BK virus (BKV) or CMV viremia compared to no viremia (p = 0.009 and p = 0.017), and no viremia was seen if immune response was > 380. BK or JC viruria was not associated with low immune response. Immune responses did not differ between patients with high or low CADI scores or between patients with immune activation or no immune activation in biopsies. Immune response in our population was higher than previously reported without increased risk of rejections. ICFA correlated with viremia but not with findings in protocol biopsies. CONCLUSION: The optimal immune response in our population needs further studies.
Authors:
I Helanterä; P Koskinen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical nephrology     Volume:  74     ISSN:  0301-0430     ISO Abbreviation:  Clin. Nephrol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-15     Completed Date:  2010-09-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0364441     Medline TA:  Clin Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  123-31     Citation Subset:  IM    
Affiliation:
Department of Medicine, Division of Nephrology, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland. ikkahelantera@helsinki.fr
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MeSH Terms
Descriptor/Qualifier:
BK Virus / immunology
Biopsy
Cytomegalovirus Infections / diagnosis*,  immunology
Female
Graft Survival
Humans
Immunologic Tests / methods*
Immunosuppressive Agents / therapeutic use
JC Virus / immunology
Kidney Transplantation / immunology*
Linear Models
Male
Middle Aged
Polyomavirus Infections / diagnosis*,  immunology,  virology
Statistics, Nonparametric
Transplantation, Homologous
Tumor Virus Infections / diagnosis*,  immunology,  virology
Viremia / diagnosis*,  virology
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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