Document Detail


Association of hypertensive diastolic blood pressure with dyslipidemia during exercise in apparently healthy subjects.
MedLine Citation:
PMID:  18277829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Diastolic blood pressure (DBP), which is influenced by cardiac output and total peripheral resistance, normally remains stable or decreases during the transition from rest to exercise. Dyslipidemia has been shown to attenuate vasodilation, and may therefore impede the normal reduction in peripheral vascular resistance during exercise. This investigation examines differences in lipid levels between apparently healthy individuals with a normal and hypertensive DBP response to exercise. METHODS: From a pool of 275 apparently healthy subjects, 35 individuals (aged 57.8 +/- 15.0 years, 13 men and 22 women) with a normal DBP at rest (<80 mm Hg) that increased to a hypertensive level at maximal exercise (> or = 90 mm Hg) were randomly age and sex matched to 35 subjects (aged 56.5 +/- 13.4 years) with a normal DBP at rest (<80 mm Hg) that remained below a hypertensive level at maximal exercise (<90 mm Hg). RESULTS: A paired t test revealed DBP to be significantly higher in the group with an abnormal response to exercise (97.0 +/- 7.6 mm Hg vs 76.8 +/- 7.4 mm Hg; P < .001). Total cholesterol (204.2 +/- 31.2 mg/dL vs 190.6 +/- 28.9 mg/dL; P < .05) and low-density lipoprotein (126.5 +/- 30.5 mg/dL vs 109.8 +/- 25.5 mg/dL; P < .05) levels were also significantly higher in the group with an abnormal DBP response to exercise. All other variables were similar between groups. DISCUSSION: Results indicate that elevated lipid levels are associated with a hypertensive DBP response during maximal exercise in apparently healthy individuals. The abnormal DBP response to exercise observed in this study may be related to attenuated vasodilation in skeletal muscle induced by higher levels of low-density lipoprotein.
Authors:
Ross Arena; James A Arrowood; Ding-Yu Fei; Shirley Helm; Kenneth A Kraft
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of cardiopulmonary rehabilitation and prevention     Volume:  28     ISSN:  1932-7501     ISO Abbreviation:  -     Publication Date:    2008 Jan-Feb
Date Detail:
Created Date:  2008-02-18     Completed Date:  2008-03-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101291247     Medline TA:  J Cardiopulm Rehabil Prev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  38-42     Citation Subset:  IM    
Affiliation:
Department of Physiology and Physical Therapy, Virginia Commonwealth University, Health Sciences Campus, Richmond, VA 23298, USA. raarena@vcu.edu
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure / physiology
Dyslipidemias / complications,  physiopathology*
Exercise / physiology*
Female
Hemodynamics
Humans
Hypertension / etiology*
Male
Middle Aged
Vasodilation
Grant Support
ID/Acronym/Agency:
M01 RR 00065/RR/NCRR NIH HHS; R01 HL 069962/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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