| Association of hypertension with single nucleotide polymorphisms in the quantitative trait locus for abdominal obesity-metabolic syndrome on chromosome 17. | |
| | |
MedLine Citation:
|
PMID: 16511504 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Genome scan in Chinese revealed an association of blood pressure with the microsatellite marker D17S1303, which lies in a quantitative trait locus for the abdominal obesity-metabolic syndrome (AOMS2) at 17p12 on chromosome 17. We previously reported that D17S1303 was associated with hypertension and obesity. Therefore, we studied 10 single nucleotide polymorphisms (SNP) within 3 kb of D17S1303. One hundred and eighty hypertensive subjects (91 men, 89 women, age 53+/-12 years) and 180 normotensive matched controls (91 men, 89 women, age 52+/-11) were genotyped using the Sequenom genotyping platform. Allelic frequencies in these Chinese subjects differed from those reported for Caucasians. Three SNPs (rs11656507, rs1357926, rs852319) were homozygous in our subjects. The genotype frequencies of rs852320, rs852321 and rs852322 did not differ between hypertensive and normotensive subjects. However, there were significant differences for rs1525402 (P=0.048), rs2692343 (P=0.022), rs2692344 (P=0.017) and rs2321313 (P=0.028). A four-locus haplotype comprising G at rs1525402, C at rs2692343, C at rs2692344 and G at rs2321313 was associated with lower systolic blood pressure (P=0.023) and normotension (P=0.048). Our results provide further evidence that there is a gene, as yet unidentified, influencing blood pressure in the vicinity of D17S1303 in a quantitative trait locus for abdominal obesity-metabolic syndrome at 17p12. |
| | |
Authors:
|
B M Y Cheung; R Y H Leung; Y B Man; K L Ong; L Y F Wong; C P Lau; K S L Lam |
Related Documents
:
|
9774364 - G protein beta3 subunit gene variant and blood pressure variation in canadian oji-cree. 9950704 - Effects of code growth and parsimony pressure on populations in genetic programming. 8846504 - A genetic approach to the pathogenesis of primary hypertension and to its treatment. 17008614 - Heritability of mri lesion volume in cadasil: evidence for genetic modifiers. 20619854 - Ventilation practices in the neonatal intensive care unit: a cross-sectional study. 6625374 - Treatment of primary pulmonary hypertension with nifedipine. a hemodynamic and scintigr... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of human hypertension Volume: 20 ISSN: 0950-9240 ISO Abbreviation: J Hum Hypertens Publication Date: 2006 Jun |
Date Detail:
|
Created Date: 2006-05-18 Completed Date: 2006-10-26 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8811625 Medline TA: J Hum Hypertens Country: England |
Other Details:
|
Languages: eng Pagination: 419-25 Citation Subset: IM |
Copyright Information:
|
Journal of Human Hypertension (2006) 20, 419-425. doi:10.1038/sj.jhh.1002003; published online 2 March 2006. |
Affiliation:
|
Department of Medicine and Research Centre of Heart, Brain, Hormone and Healthy Aging, University of Hong Kong, Queen Mary Hospital, Hong Kong. mycheung@hkucc.hku.hk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Chi-Square Distribution Chromosomes, Human, Pair 17 / genetics* Female Gene Frequency Genotype Haplotypes Hong Kong / epidemiology Humans Hypertension / epidemiology, genetics* Male Metabolic Syndrome X / epidemiology, genetics* Middle Aged Polymorphism, Single Nucleotide* Quantitative Trait Loci Statistics, Nonparametric |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Involvement of Akt in preconditioning-induced tolerance to ischemia in PC12 cells.
Next Document: Statins: another class of antihypertensive agents?