Document Detail


Association of hypertension with single nucleotide polymorphisms in the quantitative trait locus for abdominal obesity-metabolic syndrome on chromosome 17.
MedLine Citation:
PMID:  16511504     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Genome scan in Chinese revealed an association of blood pressure with the microsatellite marker D17S1303, which lies in a quantitative trait locus for the abdominal obesity-metabolic syndrome (AOMS2) at 17p12 on chromosome 17. We previously reported that D17S1303 was associated with hypertension and obesity. Therefore, we studied 10 single nucleotide polymorphisms (SNP) within 3 kb of D17S1303. One hundred and eighty hypertensive subjects (91 men, 89 women, age 53+/-12 years) and 180 normotensive matched controls (91 men, 89 women, age 52+/-11) were genotyped using the Sequenom genotyping platform. Allelic frequencies in these Chinese subjects differed from those reported for Caucasians. Three SNPs (rs11656507, rs1357926, rs852319) were homozygous in our subjects. The genotype frequencies of rs852320, rs852321 and rs852322 did not differ between hypertensive and normotensive subjects. However, there were significant differences for rs1525402 (P=0.048), rs2692343 (P=0.022), rs2692344 (P=0.017) and rs2321313 (P=0.028). A four-locus haplotype comprising G at rs1525402, C at rs2692343, C at rs2692344 and G at rs2321313 was associated with lower systolic blood pressure (P=0.023) and normotension (P=0.048). Our results provide further evidence that there is a gene, as yet unidentified, influencing blood pressure in the vicinity of D17S1303 in a quantitative trait locus for abdominal obesity-metabolic syndrome at 17p12.
Authors:
B M Y Cheung; R Y H Leung; Y B Man; K L Ong; L Y F Wong; C P Lau; K S L Lam
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of human hypertension     Volume:  20     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-18     Completed Date:  2006-10-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  419-25     Citation Subset:  IM    
Copyright Information:
Journal of Human Hypertension (2006) 20, 419-425. doi:10.1038/sj.jhh.1002003; published online 2 March 2006.
Affiliation:
Department of Medicine and Research Centre of Heart, Brain, Hormone and Healthy Aging, University of Hong Kong, Queen Mary Hospital, Hong Kong. mycheung@hkucc.hku.hk
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MeSH Terms
Descriptor/Qualifier:
Chi-Square Distribution
Chromosomes, Human, Pair 17 / genetics*
Female
Gene Frequency
Genotype
Haplotypes
Hong Kong / epidemiology
Humans
Hypertension / epidemiology,  genetics*
Male
Metabolic Syndrome X / epidemiology,  genetics*
Middle Aged
Polymorphism, Single Nucleotide*
Quantitative Trait Loci
Statistics, Nonparametric

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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