Document Detail


Association of hyperhomocysteinemia in Alzheimer disease with elevated neopterin levels.
MedLine Citation:
PMID:  15494618     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In patients with dementias including Alzheimer disease (AD), elevated blood concentrations of homocysteine are common, often going along with low normal folate and vitamin B12. Immune activation leading to oxidative stress also seems to play an important role in the pathogenesis of AD. To find out a possible relationship between immune activation and the development of moderate hyperhomocysteinemia, we determined serum concentrations of homocysteine, folate, vitamin B12 and immune activation markers 75 kD soluble TNF receptor (sTNF-R75) and neopterin in 38 patients with clinically diagnosed AD. A subgroup of patients (45%) presented with increased homocysteine concentrations in comparison to reference ranges in healthy controls of similar age. Also, concentrations of immune activation markers were elevated in a significant proportion of patients. In 17 patients with moderate hyperhomocysteinemia, concentrations of neopterin were higher than in those with lower homocysteine (p < 0.001). Homocysteine correlated with folate (rs= -0.43; p < 0.01) and neopterin (rs= 0.506; p < 0.001). The data suggest that immune activation and concomitant production of reactive oxygen species in patients with AD could be involved in the development of hyperhomocysteinemia via an enhanced decomposition of folate.
Authors:
Katharina Schroecksnadel; Friedrich Leblhuber; Barbara Frick; Barbara Wirleitner; Dietmar Fuchs
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Alzheimer disease and associated disorders     Volume:  18     ISSN:  0893-0341     ISO Abbreviation:  Alzheimer Dis Assoc Disord     Publication Date:    2004 Jul-Sep
Date Detail:
Created Date:  2004-10-20     Completed Date:  2004-12-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8704771     Medline TA:  Alzheimer Dis Assoc Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  129-33     Citation Subset:  IM    
Affiliation:
Institute of Medical Chemistry and Biochemistry, Medical University of Innsbruck, Innsbruck, Austria.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Alzheimer Disease / complications*
Female
Folic Acid / metabolism
Humans
Hyperhomocysteinemia / etiology,  physiopathology*
Immune System / physiology
Male
Middle Aged
Neopterin / blood*
Reactive Oxygen Species
Chemical
Reg. No./Substance:
0/Reactive Oxygen Species; 59-30-3/Folic Acid; 670-65-5/Neopterin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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