Document Detail

Association of human papillomavirus subtype and clinical course in respiratory papillomatosis.
MedLine Citation:
PMID:  6318005     Owner:  NLM     Status:  MEDLINE    
The relationship of human papillomavirus type 6 (HPV-6) subtypes to the clinical manifestations of respiratory papillomatosis was investigated. DNA was isolated from biopsy specimens of 21 patients and the viral genome analyzed by molecular hybridization. Four subtypes, designated HPV-6c through HPV-6f, were distinguishable by restriction endonuclease cleavage patterns of the viral genome. Patient records were reviewed to identify associations between viral subtype and sex, race, age at onset of papilloma, duration of disease, frequency of operations, history of tracheotomy and anatomical extension of papilloma. HPV-6c was present in 13 cases which were characterized by extensive anatomical spread of disease, higher frequency of operations, and a need for tracheotomy. HPV-6d occurred in 4 black patients with juvenile onset papilloma. HPV-6c was found in 2 white patients--1 with juvenile onset and 1 with adult onset papilloma. HPV-6f was identified in 2 white patients with adult onset disease.
P Mounts; H Kashima
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Laryngoscope     Volume:  94     ISSN:  0023-852X     ISO Abbreviation:  Laryngoscope     Publication Date:  1984 Jan 
Date Detail:
Created Date:  1984-02-24     Completed Date:  1984-02-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  28-33     Citation Subset:  IM    
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MeSH Terms
Genes, Viral
Middle Aged
Papillomaviridae / classification*,  genetics
Respiratory Tract Infections / diagnosis*,  microbiology,  surgery
Tumor Virus Infections / diagnosis*,  microbiology,  surgery
Grant Support
1 PO1 AI 16959-01/AI/NIAID NIH HHS; 2 S07 RR 05445-20/RR/NCRR NIH HHS

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