Document Detail


Association of homocysteine thiolactonase activity and PON1 polymorphisms with the severity of acute coronary syndrome.
MedLine Citation:
PMID:  19269283     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Excess of total homocysteine (tHcy) and decrease of thiolactonase activities (HTase) have been proposed as risk factors for coronary artery diseases (CAD). OBJECTIVES: We evaluated the relationship of tHcy and HTase with paraoxonase 1 (PON1) gene polymorphism according to CAD severity. DESIGN AND METHODS: 118 healthy volunteers and 91 CAD patients were compared. RESULTS: Serum levels of tHcy and oxidized LDL (ox-LDL) increased significantly by 26% and 48% in CAD patients and were associated with significantly lower levels of HDL cholesterol (p=0.02) and 42% of decrease in HTase activities (p<0.05). In these patients the HTase activity was negatively associated with tHcy and Hs CRP levels (r=-0.622, p=0.00 and r=-0.355, p=0.007 respectively) but positively associated with apoB and triglyceride levels (r=0.35, p=0.042 and r=0.308, p=0.003 respectively). HTase activity decreased inversely to the number of affected vessels and according to PON1 polymorphism. PON1 Q192R RR and PON1 L55M MM genotypes were associated with higher HTase activities. Only PON1 L55M (MM) genotype frequency was significantly higher in CAD patients than in controls (P<0.05), while its frequency was similar between the two subgroups according to CAD severity. In a multivariate analysis, tHcy levels were the only independent factor affecting the severity of cardiovascular disease (p=0.029). CONCLUSIONS: High tHcy levels are associated with the severity of cardiovascular disease and may be partly explained by the diminished HTase activities in these patients.
Authors:
Nadia Koubaa; Amel Nakbi; Sonia Hammami; Nabil Attia; Sounira Mehri; Khaldoun Ben Hamda; Mohamed Ben Farhat; Abdelhedi Miled; Mohamed Hammami
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-06
Journal Detail:
Title:  Clinical biochemistry     Volume:  42     ISSN:  1873-2933     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-18     Completed Date:  2009-07-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  771-6     Citation Subset:  IM    
Affiliation:
Faculty of Medicine, Laboratory of Biochemistry, UR Human Nutrition and Metabolic Disorders, Avicene st 5019 Monastir, Tunisia.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aryldialkylphosphatase / genetics*,  metabolism*
Coronary Artery Disease / blood,  genetics*
Enzyme-Linked Immunosorbent Assay
Female
Genotype
Homocysteine / blood
Humans
Lipoproteins, LDL / blood
Male
Middle Aged
Polymorphism, Genetic / genetics*
Chemical
Reg. No./Substance:
0/Lipoproteins, LDL; 0/oxidized low density lipoprotein; 454-28-4/Homocysteine; EC 3.1.8.1/Aryldialkylphosphatase

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