Document Detail


Association of high serum concentration of the third component of complement (C3) with pre-existing severe coronary artery disease and new vascular events in women.
MedLine Citation:
PMID:  15530914     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Atherosclerosis is an inflammatory disease. The complement system plays an important role in the atherosclerotic process. However, lesser data is available on the possible role of C3 as a risk factor for atherosclerosis. Therefore, in a follow up study we determined C3 levels in 266 patients with pre-existing severe coronary artery disease (CAD) and compared their serum C3 concentrations with the cause of the disease. We investigated whether C3 levels predict the major complications of severe CAD during a 5-year long follow up period in patients, who have received an aorto-coronary bypass graft surgery. C3 concentrations were elevated in the patients with severe CAD compared to 182 healthy controls, and women had higher C3 concentrations than men. Pathological C3 levels (C3> or =1.8 g/L) were able to predict major complications of atherosclerosis (death by cardiac events, new acute myocardial infarction, stroke, carotid surgery and peripheral arterial disease) that developed during the follow up period only in women (OR: 4.1, 95% C.I. 1.23-13.61, p = 0.0249) independent of other risk factors for atherosclerosis. Our data supports the assumption that high C3 indicates the progression of atherosclerosis as a special marker of chronic inflammation.
Authors:
Gábor Széplaki; Zoltán Prohászka; Jeno Duba; Szabolcs Rugonfalvi-Kiss; István Karádi; Márta Kókai; Judit Kramer; George Füst; Mónika Kleiber; László Romics; Lilian Varga
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Atherosclerosis     Volume:  177     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-08     Completed Date:  2005-04-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  383-9     Citation Subset:  IM    
Affiliation:
Third Department of Internal Medicine, Faculty of Medicine, Semmelweis University, Kútvölgyi út 4 Budapest H-1125, Hungary.
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MeSH Terms
Descriptor/Qualifier:
Arteriosclerosis / immunology
Complement C3 / analysis*
Coronary Artery Bypass
Coronary Disease / complications,  immunology*
Disease Progression
Female
Follow-Up Studies
Humans
Risk Factors
Chemical
Reg. No./Substance:
0/Complement C3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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