| Association of high-dose bifonazole administration during early pregnancy and severe limb reduction defects in the newborn. | |
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MedLine Citation:
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PMID: 20014436 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Neonatal limb reduction defects may be caused by exposure to an external agent. The azole derivatives are used in the treatment of systemic and dermal mycoses. Their relative teratogenic risk is still controversial. CASES: We describe two newborns with severe limb defects who were exposed to high doses of oral (an unacceptable route) and/or intravaginal bifonazole during the entire first trimester of pregnancy. CONCLUSION: Although only two cases are insufficient to establish a relationship, our data suggest that maternal intake of bifonazole in early pregnancy poses a risk of morphogenic malformations. The literature suggests several possible mechanisms. |
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Authors:
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Nehama Linder; Mandola Amarilla; Adriana Hernandez; Tsippy Tamiri; Lea Sirota; Gil Klinger; Itzhak Levy; Paul Merlob |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Birth defects research. Part A, Clinical and molecular teratology Volume: 88 ISSN: 1542-0760 ISO Abbreviation: Birth Defects Res. Part A Clin. Mol. Teratol. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-15 Completed Date: 2010-06-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101155107 Medline TA: Birth Defects Res A Clin Mol Teratol Country: United States |
Other Details:
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Languages: eng Pagination: 201-4 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Wiley-Liss, Inc. |
Affiliation:
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Department of Neonatology, Rabin Medical Center, Petach Tikva, Israel. linderm@ netvision.net.il |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced* Abnormalities, Multiple / etiology*, pathology Antifungal Agents / administration & dosage, adverse effects* Female Humans Imidazoles / administration & dosage, adverse effects* Infant, Newborn Limb Deformities, Congenital / chemically induced*, pathology Male Maternal Exposure / adverse effects* Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 0/Imidazoles; 60628-96-8/bifonazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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