| Association of high-altitude pulmonary edema with the major histocompatibility complex. | |
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MedLine Citation:
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PMID: 9537337 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A constitutional susceptibility has been suggested in the development of high-altitude pulmonary edema (HAPE) because HAPE generally affects healthy young people, some of whom suffer recurrent episodes. We examined whether immunogenetic susceptibility is present in HAPE-susceptible subjects. METHODS AND RESULTS: The frequencies of human leukocyte antigen (HLA) alleles in 28 male and 2 female subjects with a history of HAPE were compared with those in 100 healthy volunteers. We assayed the HLA-A, -B, -C, -DR, and -DQ antigens serologically. The pulmonary hemodynamics on admission to the hospital and the ventilatory response to hypoxia and hypercapnia were retrospectively examined in 10 of the HAPE-susceptible subjects. HLA-DR6 was positive in 14 (46.7%) of the subjects with HAPE but only 16.0% of the control subjects (P=.0005), and HLA-DQ4 was positive in 12 (40.0%) of the subjects with HAPE but only 10.0% of the control subjects (P=.0001). HLA-DR6 or HLA-DQ4 was positive in 8 (100%) of the subjects with recurrent HAPE. The pulmonary arterial pressure on admission of the HLA-DR6-positive subjects with HAPE was significantly higher than that of the HLA-DR6-negative subjects with HAPE. CONCLUSIONS: There were significant associations of HAPE with HLA-DR6 and HLA-DQ4 and of pulmonary hypertension with HLA-DR6. An immunogenetic susceptibility, which is associated with HLA class II alleles located within the major histocompatibility complex, may underlie the development of HAPE, at least in some of its forms. |
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Authors:
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M Hanaoka; K Kubo; Y Yamazaki; T Miyahara; Y Matsuzawa; T Kobayashi; M Sekiguchi; M Ota; H Watanabe |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Circulation Volume: 97 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1998 Mar |
Date Detail:
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Created Date: 1998-04-16 Completed Date: 1998-04-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1124-8 Citation Subset: AIM; IM; S |
Affiliation:
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First Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Altitude Sickness / genetics*, immunology* Anoxia / genetics, immunology Female HLA Antigens / genetics, immunology* Histocompatibility Testing Humans Hypercapnia / genetics, immunology Hypertension, Pulmonary / genetics, immunology Male Middle Aged Pulmonary Circulation Pulmonary Edema / genetics*, immunology* Respiratory Function Tests Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/HLA Antigens |
| Comments/Corrections | |
Comment In:
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Circulation. 1998 Mar 31;97(12):1111-3
[PMID:
9537335
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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