| Association of hepatitis C virus seropositivity with inflammatory markers and heart failure in persons with coronary heart disease: data from the Heart and Soul study. | |
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MedLine Citation:
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PMID: 19477406 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: How hepatitis C virus (HCV) affects coronary heart disease (CHD) risk factors and outcomes is largely unknown. METHODS AND RESULTS: Among a cohort of patients with stable CHD, we examined the association between HCV seropositivity and levels of inflammatory markers (C-reactive protein [CRP], fibrinogen, interleukin-6, and tumor necrosis factor [TNF]-alpha) and risk for the following outcomes: death, cardiovascular (CV) events, and heart failure events. A total of 84 (8.6%) participants were found to be seropositive for HCV. HCV-seropositive patients were found to have significantly lower adjusted mean levels of CRP (2.6 vs. 4.4; P < .01) and fibrinogen (340 vs. 398; P < .01), but higher levels of TNF-alpha (7.1 vs. 4.8; P < .01). Age-adjusted rates for HCV seropositive vs. seronegative were as follows: death 93 vs. 42/1,000p-y (P < .01), CV events 62 vs. 40 (P=.13), and heart failure 76 vs. 29 (P < .01). After adjustment for demographic and clinical factors, HCV remained significantly associated with an increased risk for heart failure events (HR=2.13; 95% CI: 1.19-3.80). CONCLUSIONS: In this cohort with CHD, HCV seropositive participants had higher rates of death, CV events, and heart failure hospitalizations during follow-up. After adjustment for CV risk factors, HCV seropositivity remained independently associated with risk for heart failure events. |
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Authors:
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Judith I Tsui; Mary A Whooley; Alexander Monto; Karen Seal; Phyllis C Tien; Michael Shlipak |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-02-10 |
Journal Detail:
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Title: Journal of cardiac failure Volume: 15 ISSN: 1532-8414 ISO Abbreviation: J. Card. Fail. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-29 Completed Date: 2009-09-22 Revised Date: 2011-09-20 |
Medline Journal Info:
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Nlm Unique ID: 9442138 Medline TA: J Card Fail Country: United States |
Other Details:
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Languages: eng Pagination: 451-6 Citation Subset: IM |
Affiliation:
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Section of General Internal Medicine, Department of Medicine, Boston University School of Medicine/Boston Medical Center, Boston, MA 02118, USA. judith.tsui@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biological Markers / blood C-Reactive Protein / metabolism* Coronary Disease / blood, complications*, virology Female Follow-Up Studies Heart Failure, Diastolic / blood*, etiology Hepacivirus / immunology* Hepatitis C Antibodies / analysis* Humans Inflammation / blood*, virology Male Middle Aged Prognosis Prospective Studies Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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K23 AI066943-05/AI/NIAID NIH HHS; KL2RR024130/RR/NCRR NIH HHS; R01 HL079235/HL/NHLBI NIH HHS; R01 HL079235-01A1/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Hepatitis C Antibodies; 9007-41-4/C-Reactive Protein |
| Comments/Corrections | |
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