Document Detail


Association of helminth infections with increased gametocyte carriage during mild falciparum malaria in Thailand.
MedLine Citation:
PMID:  11716129     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of this study was to determine whether pre-existing helminth infections could affect sexual forms of Plasmodium falciparum. A cross-sectional case record study compared 120 mild P. falciparum malaria cases with patent gametocyte carriage and 187 without gametocytes for helminth exposure. Relevant crude odds ratios and potential confounders were included in a logistic regression model. Helminth infections were associated with the presence of gametocytes with a crude odds ratio of 1.9 (95% confidence interval = 1.1-3.3) (P = 0.01). A positive linear trend was observed between the odds of having patent gametocytemia and the number of different helminth species (P = 0.003). However, when adjusting for hemoglobin concentration the significance of the association between helminths and gametocytes disappeared (P = 0.15). Pre-existing helminth infections may increase the severity of malarial anemia and therefore increase the likelihood of carrying gametocytes. At a population level, helminth infections may thus have a significant influence on malaria transmission.
Authors:
M Nacher; P Singhasivanon; U Silachamroon; S Treeprasertsu; S Krudsood; F Gay; D Mazier; S Looareesuwan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  65     ISSN:  0002-9637     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-21     Completed Date:  2001-12-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  644-7     Citation Subset:  AIM; IM    
Affiliation:
Unité Institut National de la Santé et de la Recherche Médicale 511, Immunobiologie Cellulaire et Moléculaire des Infections Parasitaires, Faculté de Médecine Pitié-Salpétrière, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Animals
Helminthiasis / parasitology*
Helminths / isolation & purification
Hemoglobins / analysis
Humans
Malaria, Falciparum / parasitology*
Middle Aged
Plasmodium falciparum / isolation & purification*
Grant Support
ID/Acronym/Agency:
AI35827/CFDA93856/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Hemoglobins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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